External beam radiotherapy boosts to reduce the impact caused by edema in prostate permanent seed implants

Physics in Medicine and Biology
N YueM Saiful Huq

Abstract

In prostate permanent seed implants, it has been shown that edema caused by the surgical procedure decreases dose coverage and hence may reduce treatment efficacy. This reduction in treatment efficacy has been characterized by an increase in tumour cell survival, and biomathematical models have been developed to calculate the tumour cell survival increases in seed implanted prostates of different edema magnitudes and durations. External beam boosts can be utilized to neutralize the negative impact of edema so that originally desired treatment efficacy can be achieved. In this study, a linear quadratic model is used to determine fractionation sizes of the external beam boosts for both (125)I and (103)Pd seed implants. Calculations were performed for prostates of different edema magnitudes and durations, and for tumour cells of different repair rates and repopulation rates.

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C C Ling
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·F M WatermanB W Corn
Apr 16, 1998·International Journal of Radiation Oncology, Biology, Physics·B R PrestidgeJ J Prete
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·F M WatermanA P Dicker
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Jun 9, 1999·Medical Physics·N YueF M Waterman
Mar 8, 2000·International Journal of Radiation Oncology, Biology, Physics·J C BlaskoW Cavanagh
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·Z ChenR Nath
Aug 12, 2000·International Journal of Radiation Oncology, Biology, Physics·C R King
Aug 19, 2000·International Journal of Radiation Oncology, Biology, Physics·K Hausterman, J F Fowler
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·J FowlerM Ritter
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·P D GrimmW Cavanagh
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangX Allen Li
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Jian Z WangSteven J DiBiase
Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Marc A BolletRobert Huddart

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.