External beam radiotherapy in differentiated thyroid carcinoma: A systematic review

Head & Neck
Jonathan M FusseyHisham Mehanna

Abstract

External beam radiotherapy (EBRT) is not a first line treatment in differentiated thyroid carcinoma (DTC), but is recommended as an adjuvant treatment in certain cases. The evidence for EBRT in DTC is limited. A comprehensive literature search was performed. Data on patient demographics, disease stage, treatment characteristics, and outcomes were collected from included articles after quality appraisal. Sixteen articles met the inclusion criteria, with a pooled population of 5114. Only 1 study was prospective and there were no randomized controlled trials. Most of the evidence suggests that EBRT improves locoregional control in patients at high risk of locoregional recurrence. This was corroborated by analysis of pooled patient data. Available evidence suggests an improvement in locoregional control when EBRT is used in patients over the age of 45 at high risk for locoregional recurrence. However, there is a need for long-term prospective multicenter research on the subject. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2297-E2305, 2016.

References

Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E O'ConnellC L Harmer
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·J S Cooper
Aug 1, 1997·Japanese Journal of Clinical Oncology·J D LinH F Weng
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Sin Ming ChowWai Hon Lau
Feb 14, 2003·Lancet·Steven I Sherman
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Tae-Hyun KimMyung-Sun Choi
Dec 4, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Andreas SchuckNormann Willich
Dec 20, 2005·American Journal of Otolaryngology·Kenyon M MeadowsWilliam M Mendenhall
Mar 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Ki Chang KeumGwi Eon Kim
May 27, 2006·European Journal of Endocrinology·Furio PaciniUNKNOWN European Thyroid Cancer Taskforce
Feb 6, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·David Driver, H Jane Dobbs
Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·David L SchwartzAdam S Garden
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Jill FerrariTrevor D Prior
Sep 24, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SciutoC L Maini
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Sep 6, 2011·European Journal of Endocrinology·M Schlumberger, S I Sherman
Oct 19, 2013·Radiation Oncology Journal·Jeanny KwonDo Joon Park
Jul 6, 2014·Clinical Endocrinology·Petros PerrosUNKNOWN British Thyroid Association

❮ Previous
Next ❯

Citations

Apr 16, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Chenyuan LiShengrong Sun
May 27, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rodrigo Martinez-MonederoEric J Kezirian
Jun 27, 2017·Journal of Surgical Oncology·Bo-Young KimMan Ki Chung
Apr 3, 2021·Therapeutic Advances in Endocrinology and Metabolism·Latoya A Stewart, Jennifer H Kuo
Jul 22, 2021·International Journal of Particle Therapy·Nathan Y YuSamir H Patel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.