PMID: 2867546Dec 1, 1985Paper

External Ca-independent release of norepinephrine by sympathomimetics and its role in negative feedback modulation

Proceedings of the National Academy of Sciences of the United States of America
E S ViziI Zimanyi

Abstract

The release of [3H]norepinephrine from isolated mouse vas deferens has been measured. 1-Phenylephrine and 1-norepinephrine significantly enhanced the spontaneous release of radioactivity. As shown by a combination of HPLC and scintillation spectrometry, the release of total radioactivity in response to 1-phenylephrine or 1-norepinephrine consisted mainly of [3H]norepinephrine. Evidence has been obtained that the release of endogenous norepinephrine by exogenous norepinephrine and 1-phenylephrine is independent of the external Ca2+ concentration. The released endogenous norepinephrine in turn inhibits the release of norepinephrine in response to electrical field stimulation. In the presence of yohimbine, the enhancement of spontaneous release due to 1-phenylephrine (or to 1-norepinephrine) was not affected, whereas there was a significant superimposed release of [3H]norepinephrine in response to field stimulation, indicating that the inhibition of stimulation-induced norepinephrine release is an alpha 2-adrenoceptor-mediated process. An important consequence of these findings is to question previous interpretations that the effects of administration of 1-norepinephrine or 1-phenylephrine are due exclusively to their direct effec...Continue Reading

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
May 1, 1977·European Journal of Pharmacology·F LefèvreI Cavero
Jan 1, 1979·Progress in Neurobiology·E S Vizi
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Citations

Jul 4, 1998·European Journal of Pharmacology·Y UchihashiE S Vizi
Dec 2, 2000·Neurochemistry International·E SanthaZ Gerevich
Feb 1, 1992·Journal of Neurochemistry·V Adam-Vizi
Apr 1, 1991·Journal of Neurochemistry·G Lonart, M J Zigmond
Feb 5, 1990·Brain Research·G L Snyder, M J Zigmond
Feb 1, 1987·Neurochemical Research·J KapocsiE S Vizi

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