External ears for non-invasive and stable monitoring of volatile organic compounds in human blood.

Scientific Reports
Koji TomaKohji Mitsubayashi

Abstract

Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement is essential. In this study, we have investigated the possibility of external ears for stable and real-time measurement of ethanol vapour by developing a monitoring system that consisted with an over-ear gas collection cell and a biochemical gas sensor (bio-sniffer). The high sensitivity with the broad dynamic range (26 ppb-554 ppm), the high selectivity to ethanol, and the capability of the continuous measurement of the monitoring system uncovered three important characteristics of external ear-derived ethanol with alcohol intake for the first time: there is little interference from sweat glands to a sensor signal at the external ear; similar temporal change in ethanol concentration to that of breath with delayed peak time (avg. 13 min); relatively high concentration of ethanol relative to other parts of a body (external ear-derived ethanol:breath ethanol = 1:590). These features indicated the suitability of external ears for non-invasive m...Continue Reading

References

Nov 1, 1992·The Annals of Physiological Anthropology = Seiri Jinruigaku Kenkyūkai Kaishi·S J Park, T Tamura
Jul 1, 1990·Acta Oto-laryngologica·L Hergils, B Magnuson
Jun 3, 1999·Journal of the Air & Waste Management Association·J D Fenske, S E Paulson
Oct 11, 2002·Surgical and Radiologic Anatomy : SRA·Y Lee, K Hwang
Apr 12, 2003·Forensic Science International : Synergy·A W Jones, L Andersson
Aug 1, 1952·The Journal of Investigative Dermatology·W C LOBITZ, C J CAMPBELL
Apr 24, 2004·The American Journal of Surgical Pathology·Lester D R ThompsonE Leon Barnes
Dec 29, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kazutoshi NoseTakao Tsuda
Jan 15, 2008·Analytical and Bioanalytical Chemistry·Hiroyuki KudoKohji Mitsubayashi
May 21, 2008·International Journal of Cosmetic Science·K WilkeS S Biel
Aug 30, 2008·Acta Oto-laryngologica·Sancak YukselWilliam J Doyle
Oct 22, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sandra Van den VeldeMarc Quirynen
Oct 1, 2009·BMC Cancer·Amel BajtarevicAnton Amann
Jun 1, 2009·Journal of Breath Research·Jens HerbigArmin Hansel
Jul 5, 2011·Physiological Measurement·Patrik SpanělDavid Smith
Apr 29, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Paweł MochalskiAnton Amann
Aug 1, 2015·Journal of Anatomy·Neal Anthwal, Hannah Thompson
Jun 9, 2018·ACS Sensors·Ahmed H JalalShekhar Bhansali
May 30, 2019·Sensors·Bob LansdorpEvan Strenk

❮ Previous
Next ❯

Citations

Aug 30, 2021·Current Opinion in Biotechnology·Kenta IitaniGovind Rao

❮ Previous
Next ❯

Software Mentioned

GASTEC

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.