External forces influence the elastic coupling effects during cargo transport by molecular motors

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Florian BergerReinhard Lipowsky

Abstract

Cellular transport is achieved by the cooperative action of molecular motors which are elastically linked to a common cargo. When the motors pull on the cargo at the same time, they experience fluctuating elastic strain forces induced by the stepping of the other motors. These elastic coupling forces can influence the motors' stepping and unbinding behavior and thereby the ability to transport cargos. Based on a generic single motor description, we introduce a framework that explains the response of two identical molecular motors to a constant external force. In particular, we relate the single motor parameters, the coupling strength and the external load force to the dynamics of the motor pair. We derive four distinct transport regimes and determine how the crossover lines between the regimes depend on the load force. Our description of the overall cargo dynamics takes into account relaxational displacements of the cargo caused by the unbinding of one motor. For large forces and weak elastic coupling these back-shifts dominate the displacements. To develop an intuitive understanding about motor cooperativity during cargo transport, we introduce a time scale for load sharing. This time scale allows us to predict how the regulat...Continue Reading

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Citations

Jun 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·David BreuerZoran Nikoloski
Dec 6, 2019·Scientific Reports·R BlackwellA-S Smith
Mar 31, 2019·The European Physical Journal. E, Soft Matter·Yi-Ben FuPing Xie
Sep 25, 2020·Royal Society Open Science·Naruemon RueangkhamRhoda J Hawkins
May 31, 2019·Physical Review Letters·Hamid Khataee, Jonathon Howard
Jul 22, 2016·The European Physical Journal. E, Soft Matter·Deepak Bhat, Manoj Gopalakrishnan
Nov 8, 2017·Molecular Informatics·Hamidreza KhataeeAlan Wee-Chung Liew
Apr 6, 2016·The Journal of Physical Chemistry. B·Itay Peker, Rony Granek

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