External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Jay Kumar ChhablaniWilliam Freeman

Abstract

To evaluate the predictors of visual improvement using spectral-domain optical coherence tomography (SD-OCT) in eyes with resistant diabetic macular edema (DME) treated with pars plana vitrectomy. Thirty-four eyes with resistant DME were evaluated in a retrospective manner. Several SD-OCT variables including photoreceptor inner segment/outer segment (IS/OS) junction, external limiting membrane (ELM) integrity, and central macular thickness (CMT) before and after the surgery, were evaluated by two experienced observers, masked to visual acuity. The visual improvement was used as the outcome measure for a stepwise regression, while the OCT factors were used as predictors. The strongest predictor of vision improvement was pre-operative damage to the ELM (p = 0.0277) compared to IS/OS junction (p = 0.03). Pretreatment central macular thickness was a very weak predictor (p = 0.18) of visual improvement. For each percentage increase of ELM integrity there was a 0.13 letter gain in vision. ELM integrity explained 16% of the visual acuity improvement after treatment, which rose to 21% with the addition of CMT. The addition of IS/OS junction in the model did not add predictive information. Evaluation of ELM preoperatively predicts the v...Continue Reading

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Citations

Dec 18, 2013·Middle East African Journal of Ophthalmology·Vishali Gupta, J Fernando Arevalo
Feb 5, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Martin A LeitritzFaik Gelisken
Mar 8, 2016·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Jay ChhablaniSubhadra Jalali
Feb 2, 2016·Current Eye Research·Satoshi SerizawaKumiko Soejima
Jan 1, 2016·Computers in Biology and Medicine·Vineet Sunil GattaniSoumya Jana
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Apr 7, 2016·American Journal of Ophthalmology·Ilkay Kilic MuftuogluWilliam R Freeman
Aug 1, 2015·Japanese Journal of Ophthalmology·Jaeryung KimGa Eun Cho
Dec 3, 2014·American Journal of Ophthalmology·Cheryl A ArcinueWilliam R Freeman
Aug 5, 2016·Indian Journal of Ophthalmology·Swetha B VelagaJay Kumar Chhablani
Nov 11, 2016·Journal of Current Ophthalmology·Mehdi Modarres
Nov 24, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ilkay Kilic MuftuogluWilliam R Freeman
Jul 21, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Vikas AmbiyaJay Chhablani
Nov 6, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Amit MeshiWilliam R Freeman
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Oct 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shigeo YoshidaEiko Tsuiki
Dec 21, 2019·Indian Journal of Ophthalmology·Niroj K SahooJay Chhablani
Jan 28, 2017·European Journal of Ophthalmology·Ilkay K MuftuogluZeynep K Ozturker
Mar 6, 2021·International Journal of Retina and Vitreous·Sandeep SaxenaCarsten H Meyer
Jun 3, 2021·Journal of Personalized Medicine·Sagnik SenSobha Sivaprasad
Jun 12, 2021·Experimental Biology and Medicine·Xincheng YaoDavid Le
Jun 12, 2021·Investigative Ophthalmology & Visual Science·Janet R SparrowRuben Jauregui
Aug 3, 2021·Journal of Ophthalmology·Cristian MetrangoloClaudio Azzolini
Sep 17, 2021·BMC Ophthalmology·Domagoj IvastinovicAndreas Wedrich
Oct 8, 2021·European Journal of Ophthalmology·Niroj Kumar SahooJay Chhablani
Feb 5, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Betul Onal Gunay, Gurkan Erdogan

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