External Qi of Yan Xin Qigong Induces apoptosis and inhibits migration and invasion of estrogen-independent breast cancer cells through suppression of Akt/NF-kB signaling

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Xin YanXinqi Wu

Abstract

The antitumor effects of external Qi of Yan Xin Qigong (YXQ-EQ) have been widely described over the past three decades. To gain a better understanding of the mechanisms underlying YXQ-EQ's antitumor effects, in the present study we investigated its effects on growth, migration, invasion and apoptosis of breast cancer cells and the underlying molecular mechanisms. We show that YXQ-EQ treatment caused a time-dependent reduction in viability, blocked clonogenic growth and induced apoptosis in estrogen-independent breast cancer MDA-MB-231 cells. Furthermore, YXQ-EQ treatment blocked migration and invasion of MDA-MB-231 cells. Biochemically, YXQ-EQ treatment markedly inhibited constitutive and EGF-induced Akt phosphorylation. YXQ-EQ also substantially repressed NF-kappaB activity, resulting in decreased expression of anti-apoptotic Bcl-2, Bcl-X(L), XIAP and survivin proteins. These findings suggest that YXQ-EQ may induce apoptosis and inhibition of migration and invasion of MDA-MB-231 cells through the repression of Akt/NF-kappaB signaling.

Citations

Dec 15, 2015·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Shamini JainSusan Lutgendorf
May 13, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Luís Carlos MatosFernando Jorge Monteiro
Apr 6, 2019·Integrative Cancer Therapies·Peiying YangLorenzo Cohen
Apr 2, 2020·Journal of Complementary & Integrative Medicine·Luís Carlos MatosFernando Jorge Monteiro
Nov 10, 2015·Cell Biochemistry and Function·Nada H EisaMamdouh M El-Shishtawy

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