PMID: 3748445Jun 1, 1986Paper

External quality assessment in serological diagnostic virology in Norway 1982-84

NIPH Annals
M von Kraemer

Abstract

Serum specimens for external quality assessment in virology were sent as an open distribution to 10-13 clinical microbiological laboratories during the period 1982-84. Antibodies to rubella were tested by hemagglutination-inhibition (HI); other viral antibodies were tested by complement fixation (CF). The median of the antibody-titres for each annual batch of serum specimens is used to describe and evaluate the laboratory performance. Generally speaking the antibody titres in both tests were found to cover a wide range.

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.