External quantification of myocardial perfusion by exponential infusion of positron-emitting radionuclides

The Journal of Clinical Investigation
S N HackB E Sobel

Abstract

A technique was developed and evaluated using the exponential infusion of positron-emitting diffusible tracers to quantitate myocardial perfusion. The approach employs a parameter that rapidly reaches a constant value as a function of tracer delivery rate, isotope decay constant, and the monotonically increasing tissue radioactivity. Isolated rabbit hearts with controlled flow were used to evaluate the approach, because tracer kinetics in such preparations mimic those in vivo. Accordingly, exponential infusions of H2 15O and [11C]butanol were administered to 25 isolated rabbit hearts perfused with Krebs-Henseleit solution (KH) alone or KH enriched with erythrocytes (KH-RBC, hematocrit = 40). With flow varied from 1.2 to 5 ml/g per min in eight KH hearts infused with H2 15O, actual and estimated flow correlated closely (r = 0.95, n = 52 determinations). For the KH-RBC hearts, flow was varied from 0.3 to 1.5 ml/g per min. Actual and estimated flow correlated significantly for both the 14 KH-RBC hearts infused with H2 15O (r = 0.90, n = 89 determinations) and the 3 KH-RBC hearts infused with [11C]butanol (r = 0.93, n = 13 determinations). In addition, the required exponentially increasing arterial tracer concentrations were shown ...Continue Reading

References

Nov 1, 1978·Journal of Computer Assisted Tomography·M M Ter-PogossianD C Ficke
Aug 1, 1977·Circulation·H F WeichB Pitt
Nov 1, 1972·American Heart Journal·R O SmithH K Hellems
Aug 1, 1968·Circulation Research·J B BassingthwaighteD E Donald

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Citations

Mar 1, 1983·Chest·E M Geltman, B E Sobel
Nov 1, 1983·IEEE Transactions on Bio-medical Engineering·S N HackB E Sobel
Nov 1, 1985·Progress in Cardiovascular Diseases·S R BergmannB E Sobel
May 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·S L MadsenA E Martell
Oct 1, 1984·Circulation·S R BergmannB E Sobel
Sep 18, 1999·The Journal of the Acoustical Society of America·W T Fitch, J Giedd
Feb 19, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Pernille M MollerupJens-Christian Holm
Feb 8, 2011·Journal of Youth and Adolescence·Rübab G ArimJ Douglas Willms
Sep 11, 2013·Journal of the American College of Nutrition·Verena HaasKevin J Gaskin
Nov 1, 1982·Physics in Medicine and Biology·M Selikson, J Eichling
Nov 1, 1981·Hospital Practice·B E SobelE M Geltman

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