PMID: 9531378Apr 8, 1998Paper

External radiotherapy in macular degeneration: our technique, dosimetric calculation, and preliminary results

International Journal of Radiation Oncology, Biology, Physics
M AkmansuM Or

Abstract

This study was performed to determine the toxicity and efficacy of external-beam radiotherapy in patients with age-related subfoveal neovascularization. Between January 1996 and September 1996, 25 patients with a mean age of 70.5 (60-84) years were enrolled. All patients underwent fluorescein angiographic evaluation and documentation of their neovascular disease prior to irradiation. A total of 25 patients were treated with a total dose of 12 Gy in 6 fractions over 8 days. We used a lens-sparing technique and patients were treated with a single lateral 6-MV photon beam. To assess the risk of radiation carcinogenesis after treatment of age-related subfoveal neovascularization, we estimated the effective dose for a standard patient on the basis of tissue-weighting factors as defined by the International Commission on Radiological Protection (ICRP). The calculations were made with TLD on a male randophantom. The lens dose was found to be 0.217 Gy per fraction. No significant acute morbidity was noted. Visual acuity was maintained or improved in 76% and 80% of treated patients at their 1- and 3-month follow-up examinations, respectively. On angiographic imaging, there was stabilization of subfoveal neovascular membranes in 23 patie...Continue Reading

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Citations

Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Stephan GrippChristoph Althaus
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D E RoosW J Newnham
Jun 30, 2000·Clinical Eye and Vision Care·T J Stokkermans
Mar 17, 2010·Medical Physics·Michael GertnerDarius M Moshfeghi
Oct 1, 2003·Clinical & Experimental Ophthalmology·Claire Y Hooper, Robyn H Guymer
Aug 13, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Andrew A MoshfeghiDarius M Moshfeghi

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