External trigeminal nerve stimulation for drug resistant epilepsy: A randomized controlled trial.

Brain Stimulation
Francisco Gil-LópezMar Carreño

Abstract

External trigeminal nerve stimulation (ETNS) is an emergent, non-invasive neurostimulation therapy delivered bilaterally with adhesive skin electrodes. In previous studies, ETNS was associated to a decrease in seizure frequency in patients with focal drug-resistant epilepsy (DRE). To determine the long-term efficacy and tolerability of ETNS in patients with focal DRE. Moreover, to explore whether its efficacy depends on the epileptogenic zone (frontal or temporal), and its impact on mood, cognitive function, quality of life, and trigeminal nerve excitability. Forty consecutive patients with frontal or temporal DRE, unsuitable for surgery, were randomized to ETNS or usual medical treatment. Participants were evaluated at 3, 6 and 12 months for efficacy, side effects, mood scales, neuropsychological tests and trigeminal nerve excitability. Subjects had a median of 15 seizures per month and had tried a median of 12.5 antiepileptic drugs. At 12 months, percentage of responders was 50% in ETNS group and 0% in control group. Seizure frequency in ETNS group decreased by -43.5% from baseline. Temporal epilepsy subgroup responded better than frontal epilepsy subgroup (55.56% vs. 45.45%, respectively). Median stimulation intensity was 6....Continue Reading

Citations

Dec 16, 2020·Neurology India·Jasmine PariharManjari Tripathi
Apr 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Beniamina MercanteFranca Deriu
May 1, 2021·Frontiers in Neuroscience·Timothy G WhiteChunyan Li

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