External Validation of Bladder Cancer Predictive Nomograms for Recurrence, Cancer-Free Survival and Overall Survival following Radical Cystectomy

The Journal of Urology
Michael BrooksSeth P Lerner

Abstract

We externally validated 3 previously published nomograms to predicting recurrence, and cancer specific and overall survival following radical cystectomy and pelvic lymph node dissection for urothelial carcinoma of the bladder. Two surgeons from a single institution performed a total of 197 consecutive radical cystectomies and pelvic lymph node dissections for bladder cancer from January 2003 to September 2009. A total of 23 patients were excluded from analysis. Examined parameters were those used in the original nomograms, including patient age, gender, pathological T stage, N stage, tumor grade, presence of carcinoma in situ and lymphovascular invasion, neoadjuvant chemotherapy, adjuvant chemotherapy and adjuvant radiation therapy. Nomogram predictions were compared to actuarial outcomes and predictive accuracy was quantified using measures of discrimination and calibration. At the time of analysis 34 patients had experienced recurrence, of whom 28 died of disease and 6 were currently alive with disease. Discrimination at 2, 5 and 8 years was 0.776, 0.809 and 0.794 for recurrence, 0.822, 0.840 and 0.849 for cancer specific survival, and 0.812, 0.820 and 0.825, respectively, for overall survival. Calibration plots revealed nomo...Continue Reading

References

May 14, 1982·JAMA : the Journal of the American Medical Association·F E HarrellR A Rosati
Jul 4, 2001·The Journal of Urology·M W KattanP Russo
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephan MadersbacherUrs E Studer
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Oct 11, 2003·Urology·John P Stein
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonMichael W Kattan
Jul 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Bladder Cancer Nomogram ConsortiumKinjal C Vora
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahrokh F ShariatSeth P Lerner
Jul 31, 2010·Advances in Urology·Ali A Al-Zahrani
Oct 1, 2010·Annals of Surgical Oncology·Kay Washington
Jul 7, 2011·CA: a Cancer Journal for Clinicians·Andrew J Vickers

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