External validation of fatty liver index for identifying ultrasonographic fatty liver in a large-scale cross-sectional study in Taiwan

PloS One
Bi-Ling YangShou-Dong Lee

Abstract

The fatty liver index (FLI) is an algorithm involving the waist circumference, body mass index, and serum levels of triglyceride and gamma-glutamyl transferase to identify fatty liver. Although some studies have attempted to validate the FLI, few studies have been conducted for external validation among Asians. We attempted to validate FLI to predict ultrasonographic fatty liver in Taiwanese subjects. We enrolled consecutive subjects who received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009. Ultrasonography was applied to diagnose fatty liver. The ability of the FLI to detect ultrasonographic fatty liver was assessed by analyzing the area under the receiver operating characteristic (AUROC) curve. Among the 29,797 subjects enrolled in this study, fatty liver was diagnosed in 44.5% of the population. Subjects with ultrasonographic fatty liver had a significantly higher FLI than those without fatty liver by multivariate analysis (odds ratio 1.045; 95% confidence interval, CI 1.044-1.047, p< 0.001). Moreover, FLI had the best discriminative ability to identify patients with ultrasonographic fatty liver (AUROC: 0.827, 95% confidence interval, 0.822-0.831). An FLI < 25 (negative likelihood ratio ...Continue Reading

References

Oct 31, 2002·Gastroenterology·Arun J Sanyal, UNKNOWN American Gastroenterological Association
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Chien-Hua ChenSen-Kou Yueh
Nov 19, 2008·Journal of Hepatology·Jian-Gao Fan, Geoffrey C Farrell
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Valérie ParadisJacques Belghiti
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amalia GastaldelliUNKNOWN RISC Investigators
Aug 7, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M Mohsen Ibrahim
Oct 23, 2009·Journal of Hepatology·Srinivasan DasarathyArthur J McCullough
Aug 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L P PalaniappanD S Lauderdale
Aug 27, 2010·BMC Gastroenterology·Giorgio BedogniClaudio Tiribelli
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oyekoya T AyonrindeLeon A Adams
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giliola CaloriGianluca Perseghin
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donghee KimW Ray Kim
Feb 4, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Sombat TreeprasertsukPaul Angulo
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit LoombaUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Oct 26, 2012·Journal of Gastroenterology and Hepatology·Vincent Wai-Sun Wong
Jan 29, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edith M KoehlerHarry L A Janssen
Jun 12, 2013·Journal of Hepatology·Fabio NascimbeniAmedeo Lonardo
Jun 12, 2013·The American Journal of Gastroenterology·Tania M WelzelKatherine A McGlynn
Sep 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Matthew J ArmstrongWing-Kin Syn
Oct 15, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ju Dong YangAyako Suzuki
Nov 28, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Song-iee HanJunn Yanagisawa
Dec 18, 2013·Journal of Hepatology·Jenni HyysaloHannele Yki-Järvinen
May 29, 2014·World Journal of Hepatology·Robert J Wong, Aijaz Ahmed

❮ Previous
Next ❯

Citations

Jun 19, 2015·Expert Opinion on Drug Discovery·Yuan Lin, Yi Zheng
Jun 2, 2018·PloS One·Josep Franch-NadalUNKNOWN PREDAPS Study Group
Oct 1, 2016·Journal of the Chinese Medical Association : JCMA·Kuan-Chieh FangShou-Dong Lee
Sep 4, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Jae-Hyung RohIn-Whan Seong
Oct 21, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S H AhnS Hong
Feb 15, 2017·Gastroenterology Research and Practice·Yuan-Lung ChengShou-Dong Lee
Jan 1, 2021·The American Journal of Clinical Nutrition·Nynke SimonsMartijn C G J Brouwers
Dec 12, 2020·Journal of the Chinese Medical Association : JCMA·Wei-Yu KaoWeu Wang
Mar 31, 2021·Digestive Diseases and Sciences·Biyao ZouMindie H Nguyen
Aug 7, 2021·Current Medical Research and Opinion·Juana Carretero GómezJosé Carlos Arévalo Lorido
Aug 28, 2021·Diabetology & Metabolic Syndrome·Sang Youn YouMee Kyoung Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.