External validation of SAPS 3 and MPM0-III scores in 48,816 patients from 72 Brazilian ICUs

Annals of Intensive Care
Giulliana Martines MoralezORCHESTRA Study Investigators

Abstract

The performance of severity-of-illness scores varies in different scenarios and must be validated prior of being used in a specific settings and geographic regions. Moreover, models' calibration may deteriorate overtime and performance of such instruments should be reassessed regularly. Therefore, we aimed at to validate the SAPS 3 in a large contemporary cohort of patients admitted to Brazilian ICUs. In addition, we also compared the performance of the SAPS 3 with the MPM0-III. This is a retrospective cohort study in which 48,816 (medical admissions = 67.9%) adult patients are admitted to 72 Brazilian ICUs during 2013. We evaluated models' discrimination using the area under the receiver operating characteristic curve (AUROC). We applied the calibration belt to evaluate the agreement between observed and expected mortality rates (calibration). Mean SAPS 3 score was 44.3 ± 15.4 points. ICU and hospital mortality rates were 11.0 and 16.5%. We estimated predicted mortality using both standard (SE) and Central and South American (CSA) customized equations. Predicted mortality rates were 16.4 ± 19.3% (SAPS 3-SE), 21.7 ± 23.2% (SAPS 3-CSA) and 14.3 ± 14.0% (MPM0-III). Standardized mortality ratios (SMR) obtained for each model were:...Continue Reading

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Citations

Jan 28, 2018·Critical Care : the Official Journal of the Critical Care Forum·Rashan HaniffaNicolette F De Keizer
Jan 22, 2019·Critical Care Research and Practice·Wesley Henrique Bueno de CamargoCintia Magalhães Carvalho Grion
Nov 15, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Youfeng ZhuJianrui Wei

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Software Mentioned

R
Epimed Monitor System
SPSS
GiViTI

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