External validation of the Mayo Clinic cancer specific survival score in a Japanese series of clear cell renal cell carcinoma

The Journal of Urology
Yasuhisa FujiiKazunori Kihara

Abstract

We validated the Mayo Clinic SSIGN (stage, size, grade and necrosis) score in an independent Japanese sample of patients. Between 1985 and 2006, 406 consecutive Japanese patients underwent nephrectomy for clear cell renal cell carcinoma. The prognostic value of pathological features for disease specific survival was evaluated using the Cox proportional hazards regression model. The predictive ability of the SSIGN score was evaluated using the concordance index. Median followup in the 406 patients was 56 months. Of the patients 100 died of renal cell carcinoma and the 5-year cancer specific survival rate was 78.4%. All features comprising the SSIGN score were significantly associated with death from renal cell carcinoma on univariate analysis. Primary tumor classification, regional lymph node involvement, distant metastasis and Fuhrman nuclear grade were significantly associated with death from renal cell carcinoma in a multivariate setting. The median SSIGN score in the 406 patients was 3 (range 0 to 15). The concordance index of the SSIGN score was 0.814. The 5-year cancer specific survival rate in patients with a score of 0 to 2, 3 or 4, 5 or 6, 7 to 9 and 10 or more was 96.8%, 92.5%, 78.8%, 57.7% and 18.1%, respectively. The...Continue Reading

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Citations

Apr 7, 2010·World Journal of Urology·Alessandro Volpe, Jean Jacques Patard
Jul 20, 2012·Japanese Journal of Clinical Oncology·Kenjiro SuzukiMototsugu Oya
Oct 16, 2012·Seminars in Diagnostic Pathology·Adeboye O Osunkoya, David J Grignon
May 12, 2012·European Urology·Malek MeskawiPierre I Karakiewicz
Jul 19, 2011·Hematology/oncology Clinics of North America·Patricia A TangDaniel Y C Heng
Sep 29, 2009·Urology·Hendrik IsbarnPierre I Karakiewicz
May 20, 2009·The Journal of Urology·R Houston ThompsonPaul Russo
Apr 11, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Rajan VeeratterapillayRakesh Heer
Nov 17, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Robert C FlaniganCory M Hugen
Jun 9, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·José Pedro LavradorSérgio Livraghi
Jun 26, 2017·Cancer Causes & Control : CCC·Samuel O AntwiAlexander S Parker
Feb 13, 2013·Urologia·Stefano LegramantiClaudio Simeone
Jan 26, 2013·The American Journal of Surgical Pathology·Brett DelahuntJohn C Cheville

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