External validation of the OHTS-EGPS model for predicting the 5-year risk of open-angle glaucoma in ocular hypertensives.

The British Journal of Ophthalmology
Yemisi TakwoingiSurveillance for Ocular Hypertension Study Group

Abstract

To independently evaluate and compare the performance of the Ocular Hypertension Treatment Study-European Glaucoma Prevention Study (OHTS-EGPS) prediction equation for estimating the 5-year risk of open-angle glaucoma (OAG) in four cohorts of adults with ocular hypertension. Data from two randomised controlled trials and two observational studies were analysed individually to assess transferability of the prediction equation between different geographical locations and settings. To make best use of the data and to avoid bias, missing predictor values were imputed using multivariate imputation by chained equations. Using the OHTS-EGPS risk prediction equation, predicted risk was calculated for each patient in each cohort. We used the c-index, calibration plot and calibration slope to evaluate predictive ability of the equation. Analyses were based on 393, 298, 188 and 159 patients for the Rotterdam, Moorfields, Dunfermline, and Nottingham cohorts, respectively. The discriminative ability was good, with c-indices between 0.69 and 0.83. In calibration analyses, the risk of OAG was generally overestimated, although for the Rotterdam cohort the calibration slope was close to 1 (1.09, 95% CI 0.72 to 1.46), the ideal value when there ...Continue Reading

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Citations

Dec 15, 2015·The British Journal of Ophthalmology·R HernándezUNKNOWN Surveillance of Ocular Hypertension Study group
May 20, 2018·The British Journal of Ophthalmology·Samantha SiiPankaj Kumar Agarwal
Nov 17, 2015·Current Opinion in Ophthalmology·Anja Tuulonen
Mar 4, 2015·The British Journal of Ophthalmology·Poemen P M ChanNathan Congdon
May 31, 2019·BMJ : British Medical Journal·Romin PajouheshniaKarel G M Moons

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