External Validation of the "Quick" Pediatric Logistic Organ Dysfunction-2 Score Using a Large North American Cohort of Critically Ill Children With Suspected Infection

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Matthias GörgesNiranjan Kissoon

Abstract

A quick Pediatric Logistic Organ Dysfunction 2 score on day 1, consisting of tachycardia, hypotension, and altered mentation, was shown to predict mortality with an area under the receiver operating characteristic curve of 82% (95% CI, 76-87%) in children admitted to a PICU with suspected infection. We performed an external validation of the quick Pediatric Logistic Organ Dysfunction 2, including its performance in predicting mortality in specific age groups. Analysis of retrospective data obtained from the Virtual Pediatric Systems PICU registry. Prospectively collected clinical records from 130 participating PICUs in North America. Children admitted between January 2009 and December 2014, with a diagnosis of infection at discharge, for whom all required data were available. None. Systolic blood pressures, heart rates, and Glasgow Coma Scale scores were used to evaluate the quick Pediatric Logistic Organ Dysfunction 2 using area under the receiver operating characteristic curve analysis. Performance was compared with Pediatric Risk of Mortality 3 and Pediatric Index of Mortality 2 risk scores. Data from 42,196 children with complete data were analyzed, with median age 2.7 years (interquartile range, 0.7-8.8 yr; range 0-18 yr) ...Continue Reading

References

May 1, 1996·Critical Care Medicine·M M PollackU E Ruttimann
Jan 24, 2003·Intensive Care Medicine·Anthony SlaterUNKNOWN Paediatric Index of Mortality (PIM) Study Group
Sep 25, 2003·Journal of Clinical Epidemiology·S E BleekerK G M Moons
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Jul 9, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Bassam M Gebara
May 21, 2013·Critical Care Medicine·Stéphane LeteurtreUNKNOWN Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP)
Mar 4, 2015·American Journal of Respiratory and Critical Care Medicine·Scott L WeissUNKNOWN Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investiga
Aug 13, 2015·BMJ : British Medical Journal·Menelaos PavlouRumana Z Omar
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 29, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·John S GiulianoUNKNOWN Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Netw
Jun 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Niranjan Kissoon
Dec 19, 2016·Intensive Care Medicine·Matko MarlaisDavid Inwald
Jan 24, 2017·JAMA : the Journal of the American Medical Association·François LamontagneKathryn M Rowan
May 12, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Francis LeclercUNKNOWN Groupe Francophone de Réanimation et Urgences Pédiatriques (GFRUP)
Jun 29, 2017·The New England Journal of Medicine·Konrad ReinhartSimon Finfer
Dec 6, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Danny EytanPeter C Laussen
Mar 24, 2018·Intensive Care Medicine·Francis LeclercLuregn J Schlapbach
Apr 10, 2018·Frontiers in Pediatrics·Robert J SepanskiArno L Zaritsky

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Citations

Sep 25, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jonathan SteifMatthias Görges

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