External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis.

Journal of Thrombosis and Haemostasis : JTH
Anat RabinovichATTRACT Trial Investigators

Abstract

Using data from the SOX Trial, we recently developed a clinical prediction model for occurrence of the postthrombotic syndrome (PTS) after proximal deep vein thrombosis (DVT), termed the SOX-PTS score. The score includes anatomical extent of DVT; body mass index; and baseline Villalta score. To externally validate the SOX-PTS score. Logistic regression analysis of data from the ATTRACT Trial that evaluated pharmacomechanical catheter directed thrombolysis in patients with proximal DVT. The primary outcome was the occurrence of PTS (defined as Villalta score ≥ 5) from 6 to 24 months after DVT. Secondary outcomes included moderate-severe PTS (Villalta scale ≥ 10) and severe PTS (Villalta scale ≥ 14). Predictive performance was assessed by discrimination and calibration. An updated score was evaluated in an exploratory analysis. Six hundred and ninety-one ATTRACT patients were included, of whom 328 (47%) developed PTS. The c-statistic was 0.63; 95% confidence interval (CI) 0.59-0.67 for PTS. The model's performance appeared to be better for the outcomes moderate to severe PTS and severe PTS (c-statistic 0.67; 95% CI 0.62-0.72 for moderate-severe PTS and 0.70; 0.64-0.77 for severe PTS). An updated model with age as an additional va...Continue Reading

References

Sep 26, 2001·Archives of Internal Medicine·J S GinsbergM Gent
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·C J J van DongenB A Hutten
Nov 20, 2008·Annals of Internal Medicine·Susan R KahnJeffrey S Ginsberg
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·J M T HendriksenJ A H de Groot
Jul 9, 2014·Journal of Vascular and Interventional Radiology : JVIR·Suresh VedanthamUNKNOWN Society of Interventional Radiology and Cardiovascular and Interventional Radiological Society of Europe Standards of Practi
Dec 2, 2017·Journal of Thrombosis and Haemostasis : JTH·A RabinovichUNKNOWN SOX Trial investigators
Dec 7, 2017·The New England Journal of Medicine·Suresh VedanthamUNKNOWN ATTRACT Trial Investigators
Mar 17, 2018·Blood·Anat Rabinovich, Susan R Kahn

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