Extinction Dynamics of the Foot-and-Mouth Disease Virus Carrier State Under Natural Conditions

Frontiers in Veterinary Science
Miranda R BertramJonathan Arzt

Abstract

Foot-and-mouth disease (FMD) is one of the most economically important livestock diseases worldwide. Following the clinical phase of FMD, a large proportion of ruminants remain persistently infected for extended periods. Although extinction of this carrier state occurs continuously at the animal and population levels, studies vary widely in their estimates of the duration of persistent infection. There is a need for robust statistical models to capture the dynamics of persistent infection for the sake of guiding FMD control and trade policies. The goal of the current study was to develop and assess statistical models to describe the extinction of FMD virus (FMDV) persistent infection using data from primary longitudinal studies of naturally infected cattle and Asian buffalo in Vietnam and India. Specifically, accelerated failure time (AFT) models and generalized linear mixed models (GLMM) were developed to predict the probability of persistent infection in seropositive animals and identified carriers at the individual animal level at sequential time points after outbreaks. The primary studies were analyzed by country and combined using an individual-participant data meta-analysis approach. The models estimated similar trends in...Continue Reading

References

Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·J B CondyI T Barnett
Dec 1, 1968·The Journal of Hygiene·R Burrows
Jan 1, 1970·Archiv für die gesamte Virusforschung·P J StraverJ G van Bekkum
Aug 14, 1965·The Veterinary Record·P Sutmoller, A Gaggero
Jun 8, 2002·Journal of the American Veterinary Medical Association·Johnny D CallahanWilliam M Nelson
Oct 27, 2004·Veterinary Microbiology·P MoonenA Dekker
May 3, 2005·Revue Scientifique Et Technique·A E ShawN P Ferris
Apr 19, 2008·Risk Analysis : an Official Publication of the Society for Risk Analysis· TenzinArjan Stegeman
Oct 23, 2008·PloS One·Nicholas JuleffBryan Charleston
May 5, 2010·International Journal of Epidemiology·Simon ThompsonUNKNOWN Emerging Risk Factors Collaboration
Mar 4, 2011·Transboundary and Emerging Diseases·J ArztL L Rodriguez
May 6, 2016·Journal of Virology·Carolina StenfeldtJonathan Arzt
May 12, 2016·Transboundary and Emerging Diseases·T J D Knight-JonesJ Rushton
Apr 14, 2017·Veterinary Research·Barbara BritoJonathan Arzt
May 23, 2018·Preventive Veterinary Medicine·Miranda R BertramJonathan Arzt
Apr 26, 2019·PloS One·Jonathan ArztCarolina Stenfeldt

❮ Previous
Next ❯

Citations

Sep 30, 2021·Journal of Virology·Jonathan ArztCarolina Stenfeldt

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
reverse transcription PCR

Software Mentioned

GLMM
R
AFTtools
lme4
Excel
ggplot2

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.