Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure

Brain Research Bulletin
D J Calcagnetti, M D Schechter

Abstract

It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This behavioral procedure is commonly known as the conditioned place preference (CPP)-test. At present, a firm theoretical understanding of the mechanisms underlying the production of a CPP are unknown. It is insufficient merely to know that a CPP can result after repeated drug pairings. Rather, it is necessary that the procedure is validated within a learning theory framework. The objective of the present study was, therefore, to establish that what is observed in place preference studies was, indeed, conditioning. This was accomplished by determining whether a cocaine-induced increase in time spent in a drug-paired environment was subject to attenuation following extinction trials. Rats were tested for their initial bias in spending more time in one of two stimulus-specific chambers of a place-conditioning apparatus. On four occasions, rats were injected with 2.5 mg/kg cocaine and confined to their less-preferred chamber whereas, on four alternating sessions, they were conditioned with saline...Continue Reading

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Citations

Apr 12, 2005·Pharmacology, Biochemistry, and Behavior·Francesco Leri, Zoe Rizos
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·D K MillerG R Bratton
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Suzette M EvansRichard W Foltin
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Rodrigo VallesJack R Nation
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·T A Kosten, M J Miserendino
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·D K MillerJ R Nation
Nov 14, 2002·Behavioural Brain Research·Devin MuellerJane Stewart
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Twum-Ampofo AnsahDolores C Shockley
Feb 24, 2001·Behavioural Pharmacology·C L Cunningham, C M Henderson
Jul 3, 2013·Behavioural Pharmacology·Adam D Collier, David J Echevarria
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Emmanuel ValjentJean-Antoine Girault
Jul 13, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stephanie L GrellaFrancesco Leri
Nov 8, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco LeriMary Jeanne Kreek
May 1, 2009·Expert Opinion on Drug Discovery·Erin Cummins, Francesco Leri
Feb 8, 2011·Pharmacology, Biochemistry, and Behavior·Bríd Áine Nic Dhonnchadha, Kathleen M Kantak

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