Extra- and intracellular signaling pathways under red blood cell aggregation and deformability changes

Clinical Hemorheology and Microcirculation
Alexei V MuravyovS V Bulaeva

Abstract

Exposure of red blood cells (RBCs) to catecholamines (epinephrine, phenylephrine, an agonist of alpha1-adrenergic receptors, clonidine, an agonist of alpha2-adrenergic receptors and isoproterenol, an agonist of beta-adrenergic receptors) led to change in the RBC microrheological properties. When forskolin (10 microM), an AC stimulator was added to RBC suspension, the RBC deformability (RBCD) was increased by 17% (p<0.05). Somewhat more significant deformability rise appeared after RBC incubation with dB-AMP (by 27%; p<0.01). Red blood cell aggregation (RBCA) was significantly decreased under these conditions (p<0.01). All drugs having PDE activity increased red cell deformability similarly. Some more changes of deformability was found after RBC incubation with pentoxifylline--25% (p<0.05) and IBMX incubation was accompanied only by 15% rise of RBC deformability. The drugs with PDE inhibitory activity reduced red cell aggregation. The most significant RBCA reduction effect was found under cell incubation with pentoxifylline and inhibitor PDE1-vinpocetine. On the whole RBCA reduction averaged 36% (p<0.05) under RBCs incubation with PDE inhibitors. The rise of Ca2+ influx, stimulated by A23187, was accompanied by an increase of RB...Continue Reading

Citations

Apr 18, 2018·Clinical Hemorheology and Microcirculation·Michael J FalvoMichael R Condon
Feb 28, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nadezhda N BarvitenkoOguz K Baskurt
Jun 29, 2016·Clinical & Translational Immunology·Tae-Hyung KimErica K Sloan
Sep 3, 2019·Frontiers in Physiology·Alexey N SemenovAlexander V Priezzhev

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