PMID: 7008568Feb 1, 1981Paper

Extra-adrenergic mechanisms responsible for the effects of glucose-insulin-potassium solution on vulnerability to ventricular fibrillation

The American Journal of Cardiology
W W BrooksB Lown

Abstract

In 53 chloralose-anesthetized dogs, the actions of glucose (10 mg/kg per min), insulin (0.025 U/kg per min) and potassium (0.025 mEq/kg per min) on the ventricular fibrillation and repetitive extrasystole thresholds were examined. Measurements were initially made in the control state and then repeated at 30, 60 and 120 minutes of infusion of glucose-insulin-potassium solution at a constant rate of 1.23 ml/min. The dogs received on the average 36 g of glucose, 44 U of insulin and 44 mEq of potassium over a 2 hour period. In the nonischemic myocardium, the infusion raised the threshold for ventricular fibrillation and repetitive extrasystole to a peak of 94 and 61 percent, respectively, without significantly changing serum potassium or circulating catecholamine concentration. In the ischemic myocardium, the incidence of spontaneous ventricular fibrillation during 10 minutes of coronary occlusion was reduced from 83 percent in the control state to 17 percent with glucose-insulin-potassium infusion. However, the infusion did not alter the incidence of ventricular fibrillation associated with reperfusion. Because cardio-cardiac sympathetic reflexes are elicited in response to coronary occlusion, the effect of glucose-insulin-potassi...Continue Reading

References

Jun 1, 1971·The American Journal of Cardiology·M J BurgessL S Green
Jul 1, 1970·Endocrinology·N HiattJ A Sheinkopf
May 1, 1968·Progress in Cardiovascular Diseases·B Mittra
Sep 1, 1957·Circulation Research·A CHERBAKOFFW F HAMILTON
Jan 6, 1962·JAMA : the Journal of the American Medical Association·C DANESE

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Citations

Jun 1, 1985·Journal of the American College of Cardiology·B Surawicz
Jan 30, 1986·The New England Journal of Medicine·A P HallstromR Ray
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Aziz YazarHandan çamdeviren
Feb 3, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven G CocaGregory K Buller

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