Extra copies of c-myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation

Cytometry. Part B, Clinical Cytometry
Andrea TreszlMargit Balázs

Abstract

Amplification of c-myc is a common genetic alteration and associated with a poor prognosis in a variety of cancers. Extra copies of the gene have been found in large numbers of melanoma metastases, but only few primary tumours have been studied. We investigated the c-myc copy number alterations in two different subtypes of primary melanomas with different biological behaviours. Fluorescence in situ hybridisation was performed using c-myc and centromeric 8 (C8) probes on 68 lesions (28 nodular melanomas [NMs], 26 superficial spreading melanomas [SSMs], and 14 metastases). To assess the ploidy pattern, copy number distribution of seven different chromosomes was also investigated. All tumours showed aneuploid populations for at least three chromosomes. Whereas 61% of the NMs exhibited extra c-myc copies, only 27% of SSMs showed increased gene dosage. The c-myc/C8 ratio exceeding 1.5 was significantly higher in NMs (P = 0.01). High level amplification was seen only in NMs. An elevated c-myc/C8 ratio was higher than 1.5 in only four metastases. Our data show that c-myc copy number alterations differ in the two melanoma subtypes and are associated with the advanced stage of the disease. The less frequent amplification of the c-myc ge...Continue Reading

References

May 24, 1990·The New England Journal of Medicine·J M TrentD L McGee
Feb 1, 1995·Genes, Chromosomes & Cancer·E HealyJ L Rees
Jan 1, 1993·Genes, Chromosomes & Cancer·S R WolmanM Balazs
Feb 14, 1998·The British Journal of Surgery·D A Ross, G D Wilson
Jun 2, 1998·Annals of Surgical Oncology·M M KonstadoulakisH J Wanebo
Jun 11, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·R BöniG Burg
Jul 17, 1998·British Journal of Plastic Surgery·J S ChanaA O Grobbelaar
Jul 18, 2000·Cancer·K M GreulichG Krähn
Apr 27, 2001·Journal of Dermatological Science·T Saida
Apr 28, 2001·Trends in Molecular Medicine·K SatyamoorthyM Herlyn
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Dec 26, 2001·Cancer Genetics and Cytogenetics·R N WiltshireJ M Trent
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C SchlegerU Bleyl
Jun 25, 2002·Pediatric Hematology and Oncology·Merlin R HamreRichard K Severson
Jun 25, 2002·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Robin Marks

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Citations

Mar 9, 2006·Virchows Archiv : an International Journal of Pathology·Katharina Glatz-KriegerPeter Meyer
Jun 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Véronique WinnepenninckxJoost J van den Oord
Mar 21, 2008·Pigment Cell & Melanoma Research·Dorothy C Bennett
Aug 4, 2012·PloS One·Frank M LehmannGeorg W Bornkamm
Sep 16, 2006·Journal of Cancer Research and Clinical Oncology·Denitsa KoynovaNelleke Gruis
Sep 20, 2015·Pigment Cell & Melanoma Research·Dorothy C Bennett
Jan 31, 2017·The American Journal of Dermatopathology·Fernando Cintra Lopes CarapetoGilles Landman
Mar 23, 2017·Journal of Biomedical Science·Susan MarqusTerrence J Piva
Mar 21, 2007·Pigment Cell Research·Tanja Rothhammer, Anja-Katrin Bosserhoff
Sep 16, 2005·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Attila JuhászRóza Adány
Jun 27, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Paul M HowellAdam I Riker
Dec 19, 2020·Biomedicines·Saffiya HabibMoganavelli Singh

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