Extra-intracranial blood shunt mimicking aneurysm rupture: intracranial-pressure-controlled rabbit subarachnoid hemorrhage model

Journal of Neuroscience Methods
Serge MarbacherJavier Fandino

Abstract

The achieved degree of delayed cerebral vasospasm (DCVS) in the rabbits most frequently applied cistern magna blood injection model is often mild. The aim of this study was to characterize and evaluate the feasibility of an experimental SAH technique that mimics pathophysiological mechanisms and triggers higher degrees of DCVS. SAH was induced by extracranial-intracranial (EC/IC) shunting of blood from the subclavian artery into the great cerebral cistern. Intracranial pressure (ICP), arterial blood pressure, heart rate, arterial blood gas analysis, and neurological status were monitored throughout the experiments. The magnitude of spasm was determined by comparison of pre-SAH (day 0) and post-SAH (day 3) angiograms and postmortem morphometric analysis of the basilar artery. A total of 13 experiments (SAH, n=11; controls, n=2) were performed. Two animals died after initiation of the EC/IC blood shunt in respiratory arrest. In SAH animals, ICP (baseline: 12+/-1 [mean+/-SD]; peak: 51+/-4; steady-state level: 15+/-2 mm Hg) rose to diastolic blood pressure levels (56+/-3 mm Hg) within 98+/-20s, and fell to a steady state within 186+/-41 s. SAH-induced vasoconstriction of the basilar artery was 53.1+/-2.8% on day 3 compared to basel...Continue Reading

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Citations

Oct 19, 2014·Translational Stroke Research·Serge MarbacherJavier Fandino
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Aug 26, 2011·Journal of Neuroscience Methods·Serge MarbacherJavier Fandino
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang
Aug 12, 2014·BioMed Research International·Lukas AndereggenSerge Marbacher
May 19, 2012·Journal of Neuroscience Methods·Serge MarbacherJavier Fandino
Jan 22, 2021·Journal of Atherosclerosis and Thrombosis·Chikao MiyazakiKohji Shirai

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