PMID: 10974643Sep 7, 2000Paper

Extra-pituitary growth hormone in peripheral tissues of early chick embryos

The Journal of Endocrinology
S HarveyEsmond J Sanders

Abstract

Early embryonic growth is independent of pituitary growth hormone (GH), since it occurs prior to the differentiation of pituitary somatotrophs. Embryogenesis is therefore thought to be regulated by local growth factors. As GH is now known to be produced in many extrapituitary sites, in which it acts in an autocrine or paracrine manner, the possibility that extra-pituitary GH may participate in embryogenesis and organogenesis was assessed by determining the immunocytochemical presence and location of GH- and GH-receptor (GHR)-like proteins in the peripheral tissues of chick embryos during their 21-day incubation period. Immunoreactive (IR)-GH, detectable by a monoclonal and two polyclonal antibodies for chicken GH, was specifically and ubiquitously present in tissues of 3-day-old embryos. At embryonic day (ED) 5, IR-GH was widespread in ectodermal, mesodermal and endodermal tissues, but it was not present in every cell of each tissue. IR-GH was particularly abundant i! n the neural tube, notochord, limb bud, somites, heart, stomach, liver, kidney, Wolffian duct and the amnion. By ED8, IR-GH was still widespread and was now present in limb bud cartilage, although the heart and liver were no longer GH immunoreactive. GH receptor i...Continue Reading

Citations

Jun 27, 2003·Cell and Tissue Research·M J Herrero-TurriónJ M Lara
Jul 28, 2005·Cell and Tissue Research·Jason A BeyeaSteve Harvey
Oct 26, 2010·Endocrine·S Harvey
May 26, 2005·Experimental Eye Research·Esmond J SandersSteve Harvey
Dec 12, 2001·Molecular and Cellular Endocrinology·A E Murphy, S Harvey
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M J Waters, P L Kaye
May 28, 2005·BMC Developmental Biology·Olivier BraissantClaude Bachmann
May 9, 2007·The International Journal of Developmental Biology·Lifeng WangHongwei Zhang
Apr 22, 2014·General and Comparative Endocrinology·Steve Harvey, Marie-Laure Baudet
Oct 14, 2004·Anatomy and Embryology·Esmond J Sanders, Steve Harvey
Feb 5, 2013·General and Comparative Endocrinology·Steve Harvey
Dec 28, 2010·General and Comparative Endocrinology·Esmond J SandersSteve Harvey
Mar 17, 2010·Gene Expression Patterns : GEP·Cecilia M Di PrinzioSilvia E Arranz
Jul 18, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D M KarcherT J Applegate
Mar 4, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Eduardo FuentesAlfredo Molina
Feb 17, 2007·General and Comparative Endocrinology·Steve HarveyEsmond J Sanders
Feb 23, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nicole ParkinsonAimee K Ryan
Mar 17, 2015·Molecular Reproduction and Development·Makhsud Tagirov, Serguei Golovan
Dec 11, 2014·PloS One·Makhsud Tagirov, Joanna Rutkowska
Mar 1, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jason A BeyeaSteve Harvey
May 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Esmond J Sanders, Steve Harvey
Feb 14, 2009·Endocrinology·Marie-Laure BaudetSteve Harvey
Apr 17, 2018·Endocrinology·Shutan LiaoJo K Perry
May 29, 2003·Canadian Journal of Physiology and Pharmacology·S HarveyE J Sanders
Sep 6, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xiao-Ying RuGuang-Li Li
Oct 27, 2004·General and Comparative Endocrinology·S HarveyC Aramburo
Dec 5, 2006·General and Comparative Endocrinology·Yong ZhuNhu Nguyen
Jul 3, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nhu NguyenYong Zhu

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