Extra protein loss not caused by surgical bleeding in patients with ovarian cancer

Acta Anaesthesiologica Scandinavica
M RehmU Finsterer

Abstract

[corrected] Clinical experience in patients with ovarian cancer has shown special difficulties in maintaining cardiovascular stability during surgery. To evaluate the causes for this observation, 15 patients with benign ovarian tumours (group I) and 13 patients with ovarian cancer (group II) were investigated perioperatively. Plasma volume (indocyanine green-dilution technique), haematocrit, plasma protein concentration, mean arterial pressure, heart rate, and central venous pressure were measured immediately before and after cytoreductive surgery. Normal values of blood-, plasma-, and red cell volume were determined preoperatively in both groups, and in relation to body surface area there were no intergroup differences of these parameters. In group I, the significant decrease in red cell volume of 313 ml postoperatively was compensated for by an increase in plasma volume of 371 ml (median values). In contrast to group I, the decrease in red cell volume of 328 ml in group II was not related to a significant increase in plasma volume, so that blood volume postoperatively was 483 ml lower than preoperatively, although the same standardized infusion regimen as in group I was applied. Patients of group II had a significantly higher...Continue Reading

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Citations

Mar 30, 2006·Der Anaesthesist·M JacobM Rehm
Sep 24, 2008·Der Anaesthesist·D ChappellM Rehm
Jan 30, 2014·Perioperative Medicine·Takehiko IijimaChrister H Svensen
Apr 28, 2016·Critical Care : the Official Journal of the Critical Care Forum·Åke NorbergJan Wernerman
Aug 28, 2015·PloS One·Åke NorbergJan Wernerman
Sep 25, 2008·Anesthesiology·Daniel ChappellMarkus Rehm
Mar 20, 2009·Current Opinion in Anaesthesiology·Matthias JacobMarkus W Hollmann
Feb 19, 2017·Der Anaesthesist·M RehmK Hofmann-Kiefer
Jun 13, 2017·Journal of Intensive Care·Hiroshi Ueyama, Sawami Kiyonaka
Oct 10, 2020·Der Anaesthesist·M von der ForstB H Siegler
Oct 12, 2021·Minerva anestesiologica·Giovanni SabbatiniDavide Chiumello

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