PMID: 7936715Jun 1, 1994Paper

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve

Pain
M Tal, G J Bennett

Abstract

The abnormal pain sensations that accompany peripheral neuropathies are sometimes found in a distribution that does not coincide with the territories of nerves or posterior roots. This 'extra-territorial' pain is one of the lines of evidence that has been advanced to support the proposal that these patients suffer from a psychogenic disorder. In the present experiments, rats were prepared with a unilateral chronic constriction injury (CCI) to the sciatic nerve. Beginning on the first postoperative day and continuing for at least 18 days, exaggerated withdrawal reflexes to pinprick stimulation, indicative of mechano-hyperalgesia, were seen on the side of nerve injury in the hindpaw territories of both the injured sciatic nerve and the uninjured saphenous nerve. Beginning on postoperative day 4 and continuing for at least the next 3 weeks, the withdrawal responses to von Frey hair stimulation on the nerve-injured side occurred at a significantly lower threshold, indicating the presence of mechano-allodynia. The severity and time course of the mechano-allodynia were similar in both nerve territories. When tested 18 days after the CCI, mechano-allodynia in the saphenous territory was abolished by an acute saphenous transection, but...Continue Reading

References

May 1, 1979·The Journal of Comparative Neurology·M DevorP D Wall
Mar 1, 1992·Pain·P MarchettiniS Smirne
Feb 8, 1991·The Journal of Comparative Neurology·S B McMahon, R Kett-White
Jun 1, 1987·Journal of Autism and Developmental Disorders·C A Baltaxe, D Guthrie
May 1, 1987·Archives of Neurology·R J Schwartzman, T L McLellan
Mar 1, 1961·Brain : a Journal of Neurology·A WALTERS

❮ Previous
Next ❯

Citations

Jan 1, 1994·Annals of Neurology·G J Bennett
Oct 1, 1993·Muscle & Nerve·G J Bennett
Sep 13, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ozgur GunduzAhmet Ulugol
Sep 10, 2008·Current Pain and Headache Reports·Rainer Maag, Ralf Baron
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ada DelaneySusan M Fleetwood-Walker
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·J B Siegan, J Sagen
May 28, 2003·Neuroscience Research·Andrei B PetrenkoKenji Sakimura
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 15, 2006·Nature·Christiane WetzelGary R Lewin
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Mar 13, 2002·European Journal of Pain : EJP·Per Hansson
Oct 10, 2012·British Journal of Anaesthesia·N A ManeringA Tzabazis
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Sep 12, 2008·Current Opinion in Anaesthesiology·Ke Ren, Ronald Dubner
Nov 6, 2012·Clinical and Experimental Pharmacology & Physiology·Qiu Shi WangJun Ke Wang
Jul 1, 1998·Neuromodulation : Journal of the International Neuromodulation Society·P O DahmI D Curelaru
Jan 14, 2009·The Journal of Clinical Investigation·Grewo LimJianren Mao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.