Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

The Journal of Nutritional Biochemistry
Hisham QosaAmal Kaddoumi

Abstract

Extra-virgin olive oil (EVOO) is one of the main elements of Mediterranean diet. Several studies have suggested that EVOO has several health promoting effects that could protect from and decrease the risk of Alzheimer's disease (AD). In this study, we investigated the effect of consumption of EVOO-enriched diet on amyloid- and tau-related pathological alterations that are associated with the progression of AD and cerebral amyloid angiopathy (CAA) in TgSwDI mice. Feeding mice with EVOO-enriched diet for 6months, beginning at an age before amyloid-β (Aβ) accumulation starts, has significantly reduced total Aβ and tau brain levels with a significant improvement in mouse cognitive behavior. This reduction in brain Aβ was explained by the enhanced Aβ clearance pathways and reduced brain production of Aβ via modulation of amyloid-β precursor protein processing. On the other hand, although feeding mice with EVOO-enriched diet for 3months, beginning at an age after Aβ accumulation starts, showed improved clearance across the blood-brain barrier and significant reduction in Aβ levels, it did not affect tau levels or improve cognitive functions of TgSwDI mouse. Collectively, results of this study suggest that the long-term consumption of...Continue Reading

References

Jan 29, 2003·The Journal of Nutritional Biochemistry·Kellie L. Tuck, Peter J. Hayball
Jul 30, 2003·Neurobiology of Aging·Emily J H LehmanBruce T Lamb
May 28, 2004·European Journal of Clinical Nutrition·M N VissersM B Katan
Sep 2, 2005·Nature·Gary K BeauchampPaul A S Breslin
Mar 31, 2006·The British Journal of Nutrition·Simonetta SalviniDomenico Palli
Apr 20, 2006·Annals of Neurology·Nikolaos ScarmeasJose A Luchsinger
Sep 26, 2006·Drug Discovery Today·Yan-Jiang WangXin-Fu Zhou
Oct 13, 2006·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Apr 5, 2007·Nature Protocols·Robert M J Deacon
Jul 27, 2007·Neurobiology of Disease·M Paul MurphyJeffrey N Keller
Jun 1, 2005·Nutrition Research Reviews·Elisa TripoliMaurizio La Guardia
Feb 3, 2009·Acta Neuropathologica·Khalid IqbalInge Grundke-Iqbal
Feb 11, 2009·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Mar 26, 2009·Acta Neuropathologica·Robert D Bell, Berislav V Zlokovic
May 22, 2009·Journal of Neurochemistry·John Hardy
Aug 13, 2009·JAMA : the Journal of the American Medical Association·David S Knopman
Jan 15, 2010·The British Journal of Nutrition·Vanessa PitozziLisa Giovannelli
Mar 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J López-MirandaN Yiannakouris
Apr 14, 2010·International Journal of Molecular Sciences·Sara CiceraleRussell Keast
May 1, 2010·Nature Reviews. Drug Discovery·Martin Citron
Aug 3, 2010·Trends in Endocrinology and Metabolism : TEM·Philippe LefebvreBart Staels
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·William E Van NostrandCarol A Colton
Dec 15, 2010·Science·Kwasi G MawuenyegaRandall J Bateman
Mar 10, 2011·Annals of Neurology·Nikolaos ScarmeasAdam M Brickman
Aug 16, 2011·Journal of Visualized Experiments : JoVE·Philip T T LyWeihong Song
Jan 20, 2012·Journal of Visualized Experiments : JoVE·Robert Deacon

❮ Previous
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Citations

Feb 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucía Fernández del RíoJosé M Villalba
Jan 24, 2016·Neurochemical Research·Chao-Jin XuWei-Lin Jin
Oct 21, 2016·Expert Review of Neurotherapeutics·Fiorella Casamenti, Massimo Stefani
Mar 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Syed Haris Omar
Oct 27, 2017·International Journal of Molecular Sciences·Cristina AngeloniSilvana Hrelia
Oct 27, 2017·International Journal of Molecular Sciences·Seonah LeeMira Jun
May 31, 2018·Critical Reviews in Food Science and Nutrition·Sunil K RaviBruno Vincent
Jul 5, 2019·British Journal of Pharmacology·Francesco VisioliJoao Tomé-Carneiro
Feb 20, 2020·International Journal of Molecular Sciences·Manuela LeriMassimo Stefani
Oct 23, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Shingo NakajimaHiroshi Kunugi
Dec 27, 2019·World Journal of Stem Cells·Antonio Casado-DíazJosé Manuel Quesada-Gómez
Mar 1, 2020·Scientific Reports·Youssef M MousaAmal Kaddoumi
Apr 21, 2018·Oxidative Medicine and Cellular Longevity·Joaquín G CorderoVega García-Escudero
Nov 7, 2019·Nutritional Neuroscience·Vittorio Emanuele BianchiRizzi Laura
Jun 13, 2018·Current Nutrition Reports·Hannah Gardener, Michelle R Caunca
May 15, 2019·International Journal of Molecular Sciences·Stephanie AndradeMaria do Carmo Pereira
Aug 16, 2017·Annals of Clinical and Translational Neurology·Elisabetta LaurettiDomenico Praticò
Sep 16, 2019·Revue neurologique·G C RománE Toledo
Jan 12, 2021·Frontiers in Aging Neuroscience·Mitchell Thelen, Holly M Brown-Borg
May 15, 2021·Critical Reviews in Food Science and Nutrition·Sorayya Kheirouri, Mohammad Alizadeh
May 7, 2021·Neurology·Tommaso BallariniUNKNOWN DELCODE study group

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