Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr-/-.Leiden Mice

Molecular Nutrition & Food Research
Amparo Luque-SierraLourdes M Varela

Abstract

The present study investigates the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. Ldlr-/-.Leiden mice were fed three different HFDs for 32 weeks and were compared with mice fed the standard low-fat diet (LFD). The different fats provided in the HFDs were lard (HFD-L), extra-virgin olive oil (EVOO; 79 mg kg-1 of phenolic compounds, HFD-EVOO), or EVOO rich in phenolic compounds (OL, 444 mg kg-1 of phenolic compounds, HFD-OL). All HFD-fed mice became obese, but only HFD-L-induced adipocyte hypertrophy. HFD-EVOO mice exhibited the greatest levels of Adiponectin in adipose tissue and presented atherosclerotic lesions similar to the LFD group, with a very low count of monocyte/macrophage compared with HFD-L and HFD-OL mice. Enrichment of the phenolic content of olive oil reduced the secretion of nitrites/nitrates in the aorta, but atherosclerosis was not attenuated in HFD-OL mice compared to other HFD mice. Consumption of olive oil with a natural content of phenolic compounds attenuates adipose tissue hypertrophy and inflammation and exerts antiatherosclerotic effects in mice. A higher phenolic c...Continue Reading

References

Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·L CallejaJ Osada
Dec 4, 2003·The British Journal of Nutrition·F SoriguerS Morcillo
Jun 17, 2004·Circulation·Rafael CarmenaJean-Charles Fruchart
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 5, 2006·Cardiovascular Research·Teresa A HopkinsKenneth Walsh
Jul 5, 2012·Molecular Nutrition & Food Research·José M Lou-BonafonteJesús Osada
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Yvette C LuikingNicolaas E P Deutz
Nov 29, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Aleix Sala-VilaEmilio Ros
May 3, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L Schwingshackl, G Hoffmann
Jul 6, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E GiordanoF Visioli
Oct 26, 2014·Reviews in Endocrine & Metabolic Disorders·Nora Klöting, Matthias Blüher
Oct 27, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P MulderR Kleemann
Apr 5, 2016·Diabetologia·Vanessa PellegrinelliAntonio Vidal-Puig
Jun 7, 2016·The British Journal of Nutrition·N SuganyaK M Ramkumar
Oct 22, 2016·International Journal of Endocrinology·Almudena Gómez-HernándezÓscar Escribano
Jan 26, 2017·Reviews in the Neurosciences·Jitender GairollaDheeraj Khurana
Feb 27, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M RuscicaG D Norata
Mar 25, 2017·International Journal of Molecular Sciences·Patricia Reboredo-RodríguezGiuseppe Fregapane
Mar 30, 2017·European Journal of Pharmacology·Andrea D van DamVanessa van Harmelen
May 10, 2017·European Journal of Pharmacology·Besa Emini VeseliGuido R Y De Meyer
Jun 18, 2017·Circulation·Frank M SacksUNKNOWN American Heart Association
Jul 19, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lorenzo Anez-BustillosMark Puder
Jul 20, 2017·Archives of Medical Science : AMS·Mohammed S ElluluYehia Abed
Aug 6, 2017·Biochimica Et Biophysica Acta. General Subjects·Georges N Kanaan, Mary-Ellen Harper
Nov 1, 2017·Journal of Diabetes Investigation·Miyako TanakaTakayoshi Suganami
Nov 19, 2017·Endocrine, Metabolic & Immune Disorders Drug Targets·Tanakal WongwarawipatDimitris Tousoulis

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Citations

Mar 17, 2020·Future Medicinal Chemistry·Yee-Hung Chan, Dipak P Ramji
Jun 12, 2020·International Journal of Molecular Sciences·David Johane MachateArnildo Pott
Aug 1, 2020·Foods·Cecilia Jimenez-LopezJesus Simal-Gandara
Jul 12, 2020·Biomedicines·Christina TsigalouEugenia Bezirtzoglou
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bachir Benarba, Atanasio Pandiella
Oct 31, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ilse A C ArnoldussenAmanda J Kiliaan

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