Extracellular Acid-Base Balance and Ion Transport Between Body Fluid Compartments

Physiology
Julian L Seifter, Hsin-Yun Chang

Abstract

Clinical assessment of acid-base disorders depends on measurements made in the blood, part of the extracellular compartment. Yet much of the metabolic importance of these disorders concerns intracellular events. Intracellular and interstitial compartment acid-base balance is complex and heterogeneous. This review considers the determinants of the extracellular fluid pH related to the ion transport processes at the interface of cells and the interstitial fluid, and between epithelial cells lining the transcellular contents of the gastrointestinal and urinary tracts that open to the external environment. The generation of acid-base disorders and the associated disruption of electrolyte balance are considered in the context of these membrane transporters. This review suggests a process of internal and external balance for pH regulation, similar to that of potassium. The role of secretory gastrointestinal epithelia and renal epithelia with respect to normal pH homeostasis and clinical disorders are considered. Electroneutrality of electrolytes in the ECF is discussed in the context of reciprocal changes in Cl(-) or non Cl(-) anions and [Formula: see text].

References

May 10, 1979·The New England Journal of Medicine·M Fulop
Nov 1, 1977·Anaesthesia and Intensive Care·R W Pain
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L P Karniski, P S Aronson
Jul 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R G Khalifah
Dec 1, 1980·The American Journal of Clinical Nutrition·D A SchoellerP D Klein
Apr 1, 1983·The American Journal of Physiology·S Sastrasinh, R L Tannen
Jan 1, 1993·Respiration Physiology·V Fencl, D E Leith
Apr 1, 1993·The American Journal of Physiology·R C Poole, Andrew P Halestrap
Jan 14, 1999·The American Journal of Physiology·J KereP Höglund
May 20, 1999·The Journal of Physiology·T Ma, A S Verkman
Sep 14, 1999·The American Journal of Physiology·J Katz, J A Tayek
Apr 12, 2002·The Journal of Biological Chemistry·Huasheng LuAjay Verma
Jun 25, 2002·Journal of Clinical Gastroenterology·Yaron Niv, Gerald M Fraser
Mar 26, 2003·Anesthesia and Analgesia·Peter D Constable
Sep 25, 2003·Physiological Reviews·Mitchell Chesler
Oct 9, 2003·American Journal of Physiology. Renal Physiology·Jacob LemannL Lee Hamm
Nov 17, 2004·Advances in Physiology Education·Walter F Boron
Oct 22, 2005·Experimental Physiology·Seth L Alper
Jul 13, 2006·Critical Care : the Official Journal of the Critical Care Forum·Michael Eisenhut
Aug 18, 2006·Journal of the American Society of Nephrology : JASN·Walter F Boron
Mar 1, 2008·Nature Reviews. Drug Discovery·Paul D Dobson, Douglas B Kell
Mar 25, 2008·Seminars in Nephrology·Marguerite Hatch, Robert W Freel
Apr 11, 2008·Physiology·Michael R DorwartShmuel Muallem
Oct 17, 2008·Clinical Journal of the American Society of Nephrology : CJASN·F John Gennari, Wolfgang J Weise
Sep 2, 2009·Current Genomics·P C B PereiraA C Simões E Silva
Oct 30, 2009·Journal of Cellular and Molecular Medicine·Kfir SharabiYosef Gruenbaum
Dec 10, 2009·Nature Reviews. Molecular Cell Biology·Joseph R CaseyJohn Orlowski
Apr 16, 2010·American Journal of Physiology. Renal Physiology·Helen M BeckerCarsten A Wagner
Nov 1, 2007·Journal of the American Society of Hypertension : JASH·Biff F Palmer, Amir Said Alizadeh Naderi
Oct 28, 2010·The Journal of Biological Chemistry·Ivana NovakSusanne E Hede
Sep 24, 2011·International Journal of Nephrology·Georges Deschênes, Marc Fila
Oct 22, 2011·British Journal of Pharmacology·Megan RothBruno Hagenbuch
Nov 9, 2011·Disease Models & Mechanisms·Nihed Draoui, Olivier Feron
Dec 14, 2011·IUBMB Life·Andrew P Halestrap, Marieangela C Wilson
Feb 3, 2012·Nutrition & Metabolism·Binbing LingGordon A Zello
Feb 3, 2012·Physiological Reviews·Min Goo LeeShmuel Muallem
Mar 20, 2013·Molecular Aspects of Medicine·Matthias A HedigerElspeth A Bruford
Mar 20, 2013·Molecular Aspects of Medicine·Michael F RomeroWalter F Boron
Mar 20, 2013·Molecular Aspects of Medicine·Seth L Alper, Alok K Sharma
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zaheed HusainVikas P Sukhatme
Aug 2, 2013·BMC Nephrology·Shoji TsujiKazunari Kaneko
Mar 1, 2006·Electrolyte & Blood Pressure : E & BP·Kyung Pyo KangSung Kyew Kang
Sep 23, 2014·Nature Communications·Maiyun YangPeng R Chen
Nov 6, 2014·The Journal of Biological Chemistry·Shotaro SasakiKen Iseki
Nov 13, 2014·PloS One·Alexandra SchutkowskiBettina König
Dec 6, 2014·Nature Reviews. Drug Discovery·Sanjay K Nigam
Dec 30, 2014·Physiological Reviews·Sanjay K NigamWei Wu
Jun 27, 2015·Nature Reviews. Drug Discovery·Lawrence LinKathleen M Giacomini
Oct 11, 2015·Journal of the American Society of Nephrology : JASN·Nasser A DhayatDaniel G Fuster
Nov 6, 2015·American Journal of Physiology. Renal Physiology·Susan M Wall
Feb 3, 2016·Journal of Pediatric Gastroenterology and Nutrition·Andreas R JaneckeThomas Müller
May 14, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Angus Z LauDamian J Tyler
May 1, 1963·Journal of Applied Physiology·R A MitchellJ Severinghaus

Citations

Oct 17, 2019·SLAS Technology·Antra GangulyShalini Prasad
Jul 3, 2020·International Journal of Environmental Research and Public Health·Giuliano MolinariElsa Nervo
Oct 28, 2019·Sensors·Antra Ganguly, Shalini Prasad
Jan 12, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Min-Hua TsengShih-Hua Lin

Related Concepts

Acid-Base Equilibrium
Acids
Anions
Blood
Electrolytes
Environment
Epithelial Cells
Equilibrium
Extracellular Fluid
Potassium Channel

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