Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions

PloS One
Shannan CaoYuanfu Xu

Abstract

In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.

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Citations

Nov 30, 2019·Parasitology Research·Ershun ZhouAnja Taubert
Mar 16, 2017·Frontiers in Immunology·Martina BehnenTamás Laskay
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Nov 10, 2018·Environmental Science and Pollution Research International·Seema Patel, Sushree Sangeeta

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Methods Mentioned

BETA
immunoprecipitation
pull down
chip
FACS
Light microscopy
Fluorescence

Software Mentioned

Gradientech
Tracking Tool
BD FACSDiva

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