PMID: 8974987Oct 1, 1995Paper

Extracellular adenosine 5'-triphosphate (ATP) in the endolymphatic compartment influences cochlear function

Hearing Research
David J B MunozJ M Battersby

Abstract

There is strong evidence for the presence of P2 purinoceptors on cochlear tissues, but the role of extracellular ATP in cochlear function is still unclear. Our previous studies have determined the presence of ATP in the cochlear fluids and indicated that the purinoceptors are substantially localized to the tissues lining the endolymphatic compartment. This implies that extracellular ATP may have an humoral role confined to the endolymphatic space. In order to study the influence of extracellular ATP in the endolymphatic space, a series of studies were undertaken in which ATP (10 microM to 10 mM) in artificial endolymph (EL) (test solution: 2-12.5 nl) was injected into the scala media and the effect on the cochlear microphonic (CM) and endocochlear potential (EP) evaluated. A double-barrelled pipette, with one barrel containing the test solution and the other artificial EL (control solution) was inserted into scala media of the third turn of the guinea-pig cochlea. A known volume (2-12.5 nl) of test or control solution was then pressure-injected into the space. ATP had a significant dose-dependent suppressive effect on both EP and CM with a threshold of approximately 2 x 10(-14) mol; the response was readily reversible, also in ...Continue Reading

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Citations

Apr 29, 1998·Molecular Neurobiology·G D Housley
May 21, 2008·Pflügers Archiv : European journal of physiology·Ning Yu, Hong-Bo Zhao
Feb 8, 2007·Cell and Tissue Research·Srdjan M VlajkovicPeter R Thorne
Feb 21, 2004·Journal of the Association for Research in Otolaryngology : JARO·Peter R ThorneGary D Housley
Sep 2, 2010·Purinergic Signalling·Ken Ito, Didier Dulon
May 26, 2004·Hearing Research·G D SearchfieldP R Thorne
Jun 28, 2000·Journal of the Autonomic Nervous System·G D Housley, P R Thorne
Dec 3, 1999·Brain Research. Molecular Brain Research·S M VlajkovicP R Thorne
Sep 5, 2002·Hearing Research·Srdjan M VlajkovicGary D Housley
Sep 15, 1996·Hearing Research·S M VlajkovicG D Housley
Mar 1, 1997·Hearing Research·M S FordV Ramkumar
Nov 5, 1997·Hearing Research·R A SkellettR P Bobbin
Dec 5, 1997·Hearing Research·R P BobbinM Fallon
Jun 26, 1998·Hearing Research·G D HousleyP R Thorne
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