Extracellular and circulating redox- and metalloregulated eRNA and eRNP: copper ion-structured RNA cytokines (angiotropin ribokines) and bioaptamer targets imparting RNA chaperone and novel biofunctions to S100-EF-hand and disease-associated proteins

Annals of the New York Academy of Sciences
Josef H Wissler

Abstract

Bioassays for cellular differentiation and tissue morphogenesis were used to design methods for isolation of bioactive redox- and metalloregulated nucleic acids and copper ion complexes with proteins from extracellular, circulating, wound, and supernatant fluids of cultured cells. In extracellular biospheres, diversities of nucleic acids were found to be secreted by cells upon activation. They may reflect nucleic acid biolibraries with molecular imprints of cellular history. After removal of protein components, eRNA prototypes exuded by activated cells were sequenced. They are small, endogenous, highly modified and edited, redox- and metalloregulated 5'-end phosphorylated extracellular eRNA (approximately 2-200 bases) with cellular, enzymic, and bioaptamer functions. Fenton-type OH* radical redox reactions may form modified nucleotides in RNA as wobbles eRNA per se, or as copper ion-complex with protein (e.g., S100A12-EF-hand protein, angiotropin-related protein, calgranulin-C, hippocampal neurite differentiation factor) are shown to be bioactive in vivo and in vitro as cytokines (ribokines) and as nonmitogenic angiomorphogens for endothelial cell differentiation in the formation of organoid supracellular capillary structures. ...Continue Reading

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Citations

Oct 8, 2008·Annals of the New York Academy of Sciences·Josef H WisslerEnno Logemann
Oct 17, 2015·PloS One·Yulia A ZatulovskaiaLudmila V Puchkova
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Valentin V VlassovElena Y Rykova
Aug 24, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Birgit Zimmermann-GellerElena Neumann

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