Extracellular ATP is a key modulator of alveolar bone loss in periodontitis

Archives of Oral Biology
I BindermanA Yaffe

Abstract

Periodontal diseases are initiated by pathogenic bacterial biofilm activity that induces a host inflammatory cells immune response, degradation of dento gingival fibrous tissue and its detachment from root cementum. It is well accepted, that osteoclastic alveolar bone loss is governed exclusively through secretion of proinflammatory cytokines. Nevertheless, our findings suggest that once degradation of collagen fibers by MMPs occurs, a drop of cellular strains cause immediate release of ATP from marginal gingival fibroblasts, cell deformation and influx of Ca+2. Increased extracellular ATP (eATP) by interacting with P2×7 purinoreceptors, present on fibroblasts and osteoblasts, induces generation of receptor activator of nuclear factor kB ligand (RANKL) that further activates osteoclastic alveolar bone resorption and bone loss. In addition, increased eATP levels may amplify inflammation by promoting leukocyte recruitment and NALP3-inflammasome activation via P2×7. Then, the inflammatory cells secrete cytokines, interleukin IL-1, TNF and RANKL that further trigger alveolar bone resorption. Moreover, eATP can be secreted from periodontal bacteria that may further contribute to inflammation and bone loss in periodontitis. It seems ...Continue Reading

Citations

Sep 14, 2018·Open Biology·Sasanka S Chukkapalli, Tanmay P Lele
Jan 13, 2018·Nature Reviews. Rheumatology·Matthew C WalshYongwon Choi
Jan 18, 2019·Journal of Feline Medicine and Surgery·Fernanda Maria Lopes Kubitza, James Mudie George Anthony
Aug 8, 2020·International Journal of Molecular Sciences·Daniel Spari, Guido Beldi
Nov 19, 2020·Journal of Dental Research·J S Lee, Ö Yilmaz
May 6, 2021·Biomolecules·Mariachiara ZuccariniPatrizia Di Iorio

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