Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration.

Immunology
Hiroki KawamuraToru Abo

Abstract

Macrophages are the major source of the chemokines macrophage inflammatory protein-2 (MIP-2) and keratinocyte-derived chemokine (KC), which play a major role in neutrophil migration to sites of inflammation. Although extracellular ATP from inflammatory tissues induces several immune responses in macrophages, it is unclear whether ATP-stimulated macrophages affect neutrophil migration. Therefore, the aim of the present study was to investigate the role of ATP-induced MIP-2 production by macrophages. When ATP was injected intraperitoneally into mice, the number of neutrophils within the peritoneal cavity markedly increased, along with the levels of MIP-2 and KC in the peritoneal lavage fluid. Consistent with this, ATP induced MIP-2 production, but not that of KC, by peritoneal exudate macrophages (PEMs) in vitro. This occurred via interactions with the P2X(7) receptor and P2Y(2) receptor. Furthermore, treatment of PEMs with ATP led to the production of reactive oxygen species. The ATP-induced MIP-2 production was inhibited by treatment with the antioxidant N-acetyl-l-cysteine. Also, MIP-2 production was inhibited by pre-incubating PEMs with inhibitors of extracellular signal-regulated kinase 1/2 or p38 mitogen-activated protein k...Continue Reading

References

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K A HogquistD D Chaplin
Sep 1, 1990·The Journal of Experimental Medicine·P Tekamp-OlsonA Cerami
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
May 19, 1995·The Journal of Biological Chemistry·A Ben-BaruchJ J Oppenheim
Jun 1, 1997·Current Opinion in Neurobiology·R A North, E A Barnard
Feb 13, 1999·Critical Reviews in Immunology·A ZlotnikJ A Hedrick
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·R A North, A Surprenant
Dec 21, 2000·American Journal of Physiology. Cell Physiology·R Coutinho-SilvaD M Ojcius
Mar 29, 2001·Physiological Reviews·G Vassort
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey M LabasiChristopher A Gabel
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Henry Jay Forman, Martine Torres
Dec 24, 2002·Trends in Immunology·Gilles KaplanskiCatherine Farnarier
Dec 16, 2003·Journal of Leukocyte Biology·Xiang LiHenrik Thorlacius
Aug 28, 2004·Journal of Leukocyte Biology·Hartmut Jaeschke, Mary Lynn Bajt
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroki KawamuraGunther Dennert
Jan 18, 2006·Journal of Pharmacological Sciences·Yoshiko KawaiMunekazu Gemba
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroki KawamuraGunther Dennert
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davide FerrariFrancesco Di Virgilio
Sep 19, 2006·The Journal of Biological Chemistry·Adriana del ReyPeter J Hanley
Dec 16, 2006·Science·Yu ChenWolfgang G Junger
Apr 6, 2007·Nature·Schuichi KoizumiKazuhide Inoue
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan QuGeorge R Dubyak
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katia De FilippoNancy Hogg
May 9, 2008·Cellular and Molecular Life Sciences : CMLS·W G Junger
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jay C HorvatPhilip M Hansbro
May 19, 2010·Journal of Neurochemistry·Miho ShiratoriKazuhide Inoue
Feb 22, 2012·Biochemical and Biophysical Research Communications·Ayumi KawanoShuji Kojima

❮ Previous
Next ❯

Citations

Oct 30, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Astrid KleberDarius Kubulus
Mar 20, 2014·FEBS Letters·Samantha E Adamson, Norbert Leitinger
Dec 7, 2013·British Journal of Pharmacology·J T ToguriM E M Kelly
May 9, 2014·American Journal of Reproductive Immunology : AJRI·Floor SpaansMarijke M Faas
Jan 8, 2016·Experimental Dermatology·Tomoya NakamuraTakashi Mochizuki
Oct 16, 2015·European Journal of Pharmacology·Kazuki YoshidaIsao Matsuoka
Jan 8, 2016·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Shinya OhkouchiHajime Kurosawa
Jun 25, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter StachonAndreas Zirlik
Apr 2, 2014·Hypertension·Floor SpaansMarijke M Faas
Aug 23, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ajay DixitAshok K Saluja
Feb 19, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sanooj SoniMasao Takata
Jul 8, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Vanessa F Arnaud-SampaioClaudiana Lameu
May 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manisha PandeyMichael F Good
Apr 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mikell PaigeY Michael Shim
Sep 25, 2018·Journal of Leukocyte Biology·Luke C DaviesJonathan M Weiss
Dec 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Blandine MaîtreBéatrice Hechler
Apr 13, 2018·Acta Neuropathologica Communications·Rasha Al-KhalidiDariusz C Górecki
Aug 10, 2017·Frontiers in Immunology·Maria Barberà-CremadesPablo Pelegrín
May 24, 2017·World Journal of Gastroenterology : WJG·Chao-Chao QinZhi Chen
Aug 1, 2018·Acute and Critical Care·Jin Won HuhSang-Bum Hong
Mar 31, 2019·The American Journal of Pathology·Jacob R TherkildsenHelle A Praetorius
Jun 15, 2021·Frontiers in Medicine·William T Nash, Mark D Okusa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.