Extracellular calcium causes the release of calcium from intracellular stores in chick osteocytes

Biochemical and Biophysical Research Communications
H KamiokaT Kawata

Abstract

We have recently demonstrated that a rise in the extracellular divalent cation concentration induces a rapid elevation of cytosolic calcium in chick osteocytes. Here, we demonstrate that cytosolic calcium elevation that occurs in osteocytes on exposure to elevated extracellular calcium is independent of membrane voltage and is insensitive to modulation by organic calcium channel modulators, namely, BAY K 8644, nicardipine, and nifedipine. However, the calcium elevation was sensitive to modulation by an intracellular calcium antagonist, TMB-8, suggesting that the cytosolic calcium elevation was due to mobilization of this cation from an intracellular store.

Citations

Apr 1, 2009·Therapeutic Advances in Musculoskeletal Disease·Dayong Guo, Lynda F Bonewald
Jun 18, 2004·Cell Calcium·Melita M Dvorak, Daniela Riccardi
Jan 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lynda F Bonewald
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