PMID: 9192683Jun 24, 1997Paper

Extracellular calcium sensed by a novel cation channel in hippocampal neurons

Proceedings of the National Academy of Sciences of the United States of America
Z XiongJohn F MacDonald

Abstract

Extracellular concentrations of Ca2+ change rapidly and transiently in the brain during excitatory synaptic activity. To test whether such changes in Ca2+ can play a signaling role we examined the effects of rapidly lowering Ca2+ on the excitability of acutely isolated CA1 and cultured hippocampal neurons. Reducing Ca2+ excited and depolarized neurons by activating a previously undescribed nonselective cation channel. This channel had a single-channel conductance of 36 pS, and its frequency of opening was inversely proportional to the concentration of Ca2+. The inhibition of gating of this channel was sensitive to ionic strength but independent of membrane potential. The ability of this channel to sense Ca2+ provides a novel mechanism whereby neurons can respond to alterations in the extracellular concentration of this key signaling ion.

References

Jan 1, 1992·The Journal of Physiology·S H DeVries, E A Schwartz
Jan 1, 1990·Progress in Brain Research·U HeinemannG Rausche
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C M Armstrong, C Miller
Jan 1, 1986·Experimental Brain Research·U Heinemann, B Hamon
May 6, 1984·Nature·P Hess, R W Tsien
Dec 1, 1982·Canadian Journal of Physiology and Pharmacology·K KrnjevićR J Reiffenstein
Jul 1, 1995·Pflügers Archiv : European journal of physiology·M Hoth
Jan 1, 1995·Annual Review of Physiology·H Sackin
Apr 1, 1995·The Journal of General Physiology·W Zhou, S W Jones
Jun 15, 1993·Journal of Neuroscience Research·R P MalchowH Ripps
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·M RuatS H Snyder
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Apr 15, 1993·Nature

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Citations

Jul 27, 2005·Pflügers Archiv : European journal of physiology·Michelle M Aarts, Michael Tymianski
Oct 21, 2006·Journal of Computational Neuroscience·H KagerG G Somjen
Nov 10, 2010·Journal of Physiology and Biochemistry·Xiao-Yan LiuJian-Quan Zheng
Dec 31, 2003·Cell·Michelle AartsMichael Tymianski
Nov 24, 1999·Neurochemistry International·R Clayton, J J Woodward
Dec 26, 2001·Neuroscience Letters·Akito TomomuraSetsuko Katoh
May 21, 1999·The European Journal of Neuroscience·D L WashburnA V Ferguson
Jun 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·Zhongming MaJ Kevin Foskett
Jan 30, 2004·Journal of Neurotrauma·Mark ArundineMichael Tymianski
Aug 29, 2007·Blood·Caitlin M HammondDavid E Spaner
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiang-Ping ChuZhi-Gang Xiong
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony N van den PolChristian Broberger
Jul 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica E TanisTodd Lamitina
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicholas P Vyleta, Stephen M Smith
Oct 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wen-Li WeiJohn F MacDonald
Aug 17, 2001·The Journal of Physiology·A FormentiM Martina
Mar 4, 2008·Neuropharmacology·Kresimir Krnjević
Apr 27, 2007·Neurobiology of Disease·Peter A AbdelmalikPeter L Carlen
Mar 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yaron PennElisha Moses
May 7, 2009·Journal of Neurochemistry·Robert M DietzC William Shuttleworth
Apr 21, 2007·Annals of the New York Academy of Sciences·Lech Kiedrowski
Jan 20, 2006·The FEBS Journal·Christos Chinopoulos, Vera Adam-Vizi
Sep 5, 2013·The Journal of Eukaryotic Microbiology·Helmut Plattner
Apr 12, 2016·Frontiers in Physiology·Brian L Jones, Stephen M Smith
Dec 27, 2005·Trends in Neurosciences·John F MacDonaldMichael F Jackson

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