Extracellular contrast-enhanced MRI with diffusion-weighted imaging for HCC diagnosis: prospective comparison with gadoxetic acid using LI-RADS

European Radiology
Dong Ik ChaSoo Hyun Ahn

Abstract

The aim of this study was to evaluate the diagnostic performance of introducing diffusion-weighted imaging (DWI) as a major feature to extracellular agent (ECA)-MRI for diagnosing HCC in comparison with gadoxetic acid (hepatobiliary agent, HBA)-MRI using Liver Imaging Reporting and Data System (LI-RADS) v2018. This was a prospective intra-individual comparison study using two different types of contrast agents for liver MRI conducted at a tertiary referral academic center. One hundred forty-seven observations in 122 patients at high risk for HCC scheduled for liver surgery were included. The sensitivity, specificity, and accuracy of LI-RADS category 5 (LR-5) for HCC diagnosis according to conventional and modified LI-RADS on ECA- and HBA-MRI were measured and compared. Modified LI-RADS incorporated hyperintensity on DWI as a major feature with ECA-MRI, and hypointensity on transitional phase (TP) and/or hepatobiliary phase (HBP) as washout appearance on HBA-MRI, respectively. Modified LI-RADS on ECA-MRI had higher sensitivity and accuracy than modified LI-RADS on HBA-MRI (90.3% vs. 74.9%, p < 0.001; and 91.9% vs. 76.9%, p < 0.001, respectively), as well as higher specificity, although the difference did not reach statistical si...Continue Reading

References

Dec 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alejandro FornerJordi Bruix
May 1, 2009·Journal of Gastroenterology·Masato NaritaShinji Uemoto
Dec 25, 2009·Radiology·Bachir Taouli, Dow-Mu Koh
Jun 23, 2010·AJR. American Journal of Roentgenology·Kristina I RingeElmar M Merkle
Oct 29, 2015·Radiology·Patrick M BossuytUNKNOWN STARD Group

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Citations

Feb 28, 2021·Journal of Magnetic Resonance Imaging : JMRI·Jaeseung ShinMi-Suk Park
Mar 2, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Zhichao FengPengfei Rong

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