PMID: 8592125Feb 1, 1996Paper

Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers

Journal of Neurochemistry
M Y LiM E Reith

Abstract

Monoamine-uptake blockers were applied focally (0.1-1,000 microM) through a dialysis probe in the nucleus accumbens of freely moving rats, and the extracellular concentrations of dopamine, norepinephrine, and serotonin were measured. The selective dopamine-uptake blocker GBR 12935 increased dopamine preferentially with only a small effect on norepinephrine, whereas the selective serotonin-uptake blocker fluoxetine increased serotonin output preferentially. In contrast, the selective norepinephrine-uptake blockers desipramine and nisoxetine enhanced not only norepinephrine, but also serotonin and dopamine appreciably. Cocaine increased all three amines with the greatest effects on dopamine and serotonin. As in our previous study on the ventral tegmental area, there was a positive association between dopamine and norepinephrine output when all blocker data were taken together. The present results suggest a contribution of the increase in norepinephrine, but not serotonin, to the enhancement of dopamine after cocaine applied focally in the nucleus accumbens.

Citations

Jan 26, 2000·Journal of Neurochemistry·S Rahman, W J McBride
Aug 5, 2009·Addiction Biology·Nathan S PentkowskiJanet L Neisewander
May 27, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A M SidlakM G Abesamis
Jul 9, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John R MantschHolly Caretta
Feb 24, 2012·Pharmacological Reports : PR·Joanna MiszkielEdmund Przegaliński
Nov 21, 2000·Annals of the New York Academy of Sciences·N ThirietJ Zwiller
Jul 11, 2007·The Australian and New Zealand Journal of Psychiatry·Edmund SilinsPaul Dillon
Apr 30, 2019·Frontiers in Behavioral Neuroscience·Judith Camats-PernaGert Lubec
Nov 14, 1998·Brain Research. Molecular Brain Research·N ThirietJ Zwiller
Nov 13, 2003·European Journal of Pharmacology·Richard B Rothman, Michael H Baumann

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