Extracellular fetal hemoglobin induces increases in glomerular permeability: inhibition with α1-microglobulin and tempol

American Journal of Physiology. Renal Physiology
Kristinn SverrissonBengt Rippe

Abstract

Extracellular fetal hemoglobin (HbF) and adult hemoglobin (HbA) are proinflammatory and generate ROS. Increased plasma levels of extracellular HbF have recently been reported to occur in early preeclampsia. α1-Microglobulin (A1M) is a physiological heme-binding protein and radical scavenger that has been shown to counteract vascular permeability increases induced by HbA in the perfused placenta. The present study was performed to investigate whether HbF and HbA will increase glomerular permeability in vivo and to test whether A1M and tempol, a ROS scavenger, can prevent their effects. Anesthetized Wistar rats were continuously infused intravenously with either HbA, HbF, or cyano-inactivated HbF together with FITC-Ficoll-70/400, inulin, and (51)Cr-labeled EDTA for 2 h. Plasma samples and urine samples (left ureter) were taken repeatedly and analyzed by high-performance size exclusion chromatography to assess glomerular sieving coefficients for Ficoll of radius 10-80 Å. In separate experiments, A1M or tempol was given before and during Hb infusions. Extracellular HbF caused rapid, transient increases in glomerular permeability to large Ficoll molecules (50-80Å), contrary to the effects of HbA and cyano-inactivated HbF. For HbF, g...Continue Reading

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Citations

Feb 24, 2016·Women's Health·Cherynne Johansson
Dec 24, 2015·International Journal of Molecular Sciences·Jonas AhlstedtBo Åkerström
Jan 30, 2015·Frontiers in Physiology·Stefan R HanssonLena Erlandsson
Dec 30, 2014·Frontiers in Physiology·Elena KarnaukhovaBo Åkerström
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May 14, 2016·American Journal of Physiology. Renal Physiology·Richard A ZagerKirsten Frostad
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Oct 4, 2020·International Journal of Molecular Sciences·Amanda KristianssonJill R Storry
Apr 26, 2019·Frontiers in Physiology·Grigorios KalapotharakosStefan R Hansson
Sep 30, 2016·American Journal of Physiology. Renal Physiology·Julia DolininaBengt Rippe
Mar 23, 2021·Frontiers in Physiology·Jesper BergwikBo Åkerström
Jun 22, 2021·International Journal of Biological Macromolecules·Selvaraju KanagarajanLi-Hua Zhu

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