PMID: 9446692Apr 4, 1998Paper

Extracellular glutamate increases in rostral ventrolateral medulla during static muscle contraction

Pflügers Archiv : European journal of physiology
D CaringiAhmmed Ally

Abstract

The ventrolateral medulla is an important site involved in increases in arterial pressure and heart rate during static muscle contraction. Glutamate, an excitatory amino acid neurotransmitter, appears to play a role in mediating these responses. We measured glutamate concentration in the extracellular fluid of the rostral ventrolateral medulla during static muscle contraction in anesthetized rats. A 2-min tibial nerve stimulation-evoked muscle contraction increased blood pressure by 30 +/- 4 mmHg and heart rate by 32 +/- 4 bpm. Extracellular glutamate in the rostral ventrolateral medulla also increased from 9 +/- 1 pmol/4 microl to 14 +/- 1 pmol/4 microl. Results were repeatable over two subsequent contractions. Tibial nerve stimulation following neuromuscular blockade did not elicit changes in blood pressure, heart rate or extracellular fluid glutamate. Data demonstrate that muscle contraction increases extracellular fluid concentration of glutamate in the rostral ventrolateral medulla, suggesting that rostral ventrolateral medullary glutamate release is a neurochemical change associated with cardiovascular responses during static muscle contraction.

Citations

Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takeshi IshideAhmmed Ally
Jul 9, 2002·Clinical and Experimental Pharmacology & Physiology·Takeshi IshideAhmmed Ally
Dec 18, 2001·The Journal of Physiology·S A SmithM G Garry
Feb 5, 2010·Journal of Neural Transmission·Fuad LechinMarcel E Lechin
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T IshideA Ally
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·T K GrayA Ally
Oct 1, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C Martins-Pinge
Sep 6, 2005·Autonomic Neuroscience : Basic & Clinical·Marli Cardoso Martins-PingeOswaldo Ubríaco Lopes
Jun 27, 2020·Nitric Oxide : Biology and Chemistry·Ahmmed AllySurya M Nauli

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