PMID: 6969771Dec 1, 1980Paper

Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes

The Journal of Experimental Medicine
F K StevensonA L Tutt

Abstract

The peripheral blood lymphocytes of nine out of nine patients with typical surface Ig-positive chronic lymphocytic leukemia but no paraprotein visible on serum electrophoresis have been shown by radioimmunoassay to export small amounts of pentameric IgM during culture (in the range of 2.4-7.2 ng/10(7) cells per h); three out of nine also exported monomeric IgD (0.7-1.4 ng/10(7) cells per h). Immunoglobulin turned over on the cell surface did not appear to contribute to material in the culture fluid, except possibly as vesicle-bound Ig. In three cases, which included two of the IgD producers, anti-idiotypic antibody raised against the cell surface Fab mu was used to demonstrate the idiotypic nature of the exported Ig. Anti-idiotypic antibody was also used to measure levels of idiotypic Ig in the sera of these three patients as a proportion of the total Ig. Total serum IgM was depressed in all three patients, and the idiotypic IgM represented 43%, 65%, and 96% of the IgM. The findings suggest that in typical chronic lymphocytic leukemia involving B lymphocytes, the export of a small amount of idiotypic Ig by the neoplastic cells in a common or even usual occurrence.

References

Apr 24, 1975·Nature·G T Stevenson, F K Stevenson
Oct 1, 1976·The Journal of Experimental Medicine·D W HoughG T Stevenson
Feb 28, 1978·Biochemical and Biophysical Research Communications·P J Fraker, J C Speck
Oct 21, 1976·Journal of Theoretical Biology·F Doljanski, M Kapeller
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·S M FuH G Kunkel
Aug 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J Schen, M Rabinowitz

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Citations

Aug 1, 1992·American Journal of Hematology·J JuncàE Feliu
Jul 1, 1982·Journal of Clinical Immunology·P GuglielmiM Seligmann
Apr 1, 1983·Journal of Clinical Immunology·I G Barr, B H Toh
Jan 1, 1983·Springer Seminars in Immunopathology·G T Stevenson, F K Stevenson
Dec 16, 1983·Journal of Immunological Methods·N R Ling
Dec 1, 1981·The Journal of Experimental Medicine·F K StevensonG T Stevenson
Jan 1, 1983·The Journal of Experimental Medicine·F K StevensonA L Tutt
Mar 1, 1990·The Journal of Experimental Medicine·T WenM Jondal
Aug 30, 2008·British Medical Bulletin·A D Hamblin, T J Hamblin
Aug 14, 1982·British Medical Journal·T J Hamblin
Dec 1, 1982·Journal of Clinical Pathology·G J MuftiM Fitchett
Apr 1, 1984·Journal of Clinical Pathology·D SinclairD I Stott
Feb 1, 1984·The Journal of Clinical Investigation·J CossmanA Bakhshi
May 6, 2014·Journal of Clinical Immunology·Hiromi KubagawaKazuhito Honjo
Jul 1, 1986·International Reviews of Immunology·F K Stevenson, G T Stevenson
Jan 1, 1986·Cancer Investigation·E H Lipford, J Cossman
Apr 5, 2016·Seminars in Oncology·Kerry A Rogers, Jennifer A Woyach
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Clive S Zent, Neil E Kay
Jun 11, 2014·American Journal of Hematology·Carlo ViscoFrancesco Rodeghiero
Jan 1, 1982·British Journal of Haematology·P GuglielmiM T Daniel
Dec 1, 1993·Baillière's Clinical Haematology·G Dighiero
Jan 1, 1982·Immunological Reviews·E S VitettaJ W Uhr
Mar 1, 1984·Immunology Today·F K Stevenson, J L Smith
Jan 31, 2020·Frontiers in Oncology·Bruno Fattizzo, Wilma Barcellini
Jun 1, 1987·Baillière's Clinical Haematology·T J Hamblin

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