Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma

Head & Neck
Rabeia AlmahmoudiAhmed Al-Samadi

Abstract

Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses. Mast cells are the major source of IL-17F in oral tongue SCC. In multivariate analysis, only the extracellular mast cell-derived IL-17F at the tumor invasion front was associated with better disease-specific survival in patients with all-stages and early-stages of oral tongue SCC. Extracellular mast cell-derived IL-17F is antitumorigenic in oral tongue SCC. It separates patients with early-stage disease who are at high risk from patients who are at low risk. Furthermore, when analyzing tentative prognostic molecules, we conclude that in addition to the staining intensity, attention must be paid to the cellular source, distribution, and location of the molecule.

References

Sep 6, 2000·Journal of Internal Medicine·H KuperD Trichopoulos
Nov 14, 2001·American Journal of Clinical Dermatology·J J Sciubba
Dec 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BrayD M Parkin
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Jun 9, 2007·British Journal of Haematology·Gustaf HedströmGunilla Enblad
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Feb 24, 2009·Cytokine·Seon Hee Chang, Chen Dong
Jul 4, 2009·Nature Reviews. Immunology·Sarah L Gaffen
Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
May 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew M LinAllen T Bruce
Apr 18, 2012·PloS One·Zan TongChen Dong
Apr 25, 2012·World Journal of Gastrointestinal Surgery·Noemí Eiró, Francisco J Vizoso
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jan 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liang DingYa-Yi Hou
Aug 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmed Al-SamadiFaraz Bishehsari
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rengaswamy Sankaranarayanan
Mar 6, 2016·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Aug 21, 2016·The British Journal of Dermatology·A SalemK K Eklund

❮ Previous
Next ❯

Citations

May 13, 2020·Oral Diseases·Abdelhakim Salem, Tuula Salo
Apr 13, 2019·International Journal of Molecular Sciences·Abdelhakim SalemKari K Eklund
Apr 1, 2020·Cellular Oncology (Dordrecht)·Nathalia FerreiraSara Granja
Sep 23, 2020·Head and Neck Pathology·Meri SieviläinenAhmed Al-Samadi
May 15, 2019·Cancers·Rabeia AlmahmoudiAhmed Al-Samadi
Mar 21, 2021·Cancer Science·Rabeia AlmahmoudiAhmed Al-Samadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Jeong Seok HwaRock Bum Kim
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Kyle E RusthovenChanghu Chen
© 2022 Meta ULC. All rights reserved