Extracellular levels of dopamine in the nucleus accumbens in AA and ANA rats after reverse microdialysis of ethanol into the nucleus accumbens or ventral tegmental area

Alcohol
P TuomainenK Kiianmaa

Abstract

Ethanol is known to increase the release of dopamine in the nucleus accumbens. The question of whether this is a result of a direct or an indirect effect of ethanol on mesolimbic dopaminergic neurons was examined by investigating the extracellular levels of dopamine and its metabolites in the nucleus accumbens of alcohol-preferring AA (Alko Alcohol) and alcohol-avoiding ANA (Alko Non-Alcohol) rats after application of ethanol locally into either the nucleus accumbens or the ventral tegmental area with the use of reverse microdialysis. Application of ethanol (200, 400, or 800 mM in dialysate) into the nucleus accumbens, but not into the ventral tegmental area, temporarily increased the accumbal levels of dopamine in a dose-dependent manner. The ethanol-evoked increase in the level of extracellular dopamine was more prominent in AA rats than in ANA rats. Ethanol tended to suppress levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Because the concentrations of ethanol found to elevate the extracellular level of dopamine can hardly be considered pharmacologically relevant, the increase in accumbal dopamine levels after application of ethanol may be due to nonspecific membrane effects of ethanol. The findings support t...Continue Reading

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Citations

Jan 17, 2007·Psychopharmacology·Karen K SzumlinskiM Scott Bowers
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Anna Molander, Bo Söderpalm
Aug 4, 2009·Physiology & Behavior·Jessica R BarsonBartley G Hoebel
Feb 17, 2006·European Journal of Pharmacology·Kimmo Ingman, Esa R Korpi
Apr 23, 2005·Journal of Neuroscience Research·Travis J WorstKent E Vrana
Oct 26, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdelkader Dahchour, Roberta J Ward

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