Extracellular matrices expression in invasion area of adenoid cystic carcinoma of salivary glands

Cancer Letters
S ShintaniN Terakado

Abstract

Adenoid cystic carcinoma (ACC) is a salivary malignant tumor with poor long-term prognosis, that is known to have predilection for invasion of the adjacent stroma and neural tissues. This carcinoma has shown a high incidence of recurrence and distal metastasis. Invasive carcinomas have been associated with the distributions of extracellular matrices (ECM). Cell proliferation as a marker of tumor growth has been related to poor prognosis in oral carcinomas. Immunohistochemical analysis of 15 cases of ACC was done using antibodies to laminin, type IV collagen, fibronectin, tenascin and anti-proliferating nuclear antigen (PCNA). Laminin and type IV collagen were totally or partially absent in the ACC invasive areas. Tenascin was expressed in the stroma and cytoplasm and was associated with tumor cell proliferation. It can be concluded that basement membrane represents a barrier that is lost during cell invasion and tenascin may be involved in the detachment of cancer cells, increasing the invasive potential of ACC.

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Citations

Mar 14, 2008·International Journal of Experimental Pathology·Ruy G JaegerVanessa M Freitas
Feb 8, 2005·Oral Oncology·Trent H WesternoffBrian L Schmidt
Oct 8, 2004·Histopathology·S IlmonenS Asko-Seljavaara
Apr 2, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Letícia N Gama-de-SouzaRuy G Jaeger
Apr 16, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R RaitzV C Araújo
Dec 20, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Vera Cavalcanti de AraújoNey Soares de Araújo
Aug 24, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Márcia Cristina da C MiguelLélia B de Souza

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