Extracellular matrix alterations in conventional renal cell carcinomas by tissue microarray profiling influenced by the persistent, long-term, low-dose ionizing radiation exposure in humans

Virchows Archiv : an International Journal of Pathology
A RomanenkoA Llombart-Bosch

Abstract

The present study was carried out in order to examine molecular alterations of extracellular matrix (ECM), associated with cell-cell communication in conventional (clear-cell) renal cell carcinomas (cRCCs) influenced by persistent long-term, low-dose ionizing radiation (IR) exposure to patients living more than 19 years after the Chernobyl accident in Cesium 137 (137Cs)-contaminated areas of Ukraine. The ECM major components such as fibronectin, laminin, E-cadherin/beta-catenin complexes and p53 tumor suppressor gene protein, and transforming growth factor beta 1 (TGF-beta1) were immunohistochemically (IHC) evaluated in cRCCs from 59 Ukrainian patients, which represented 18 patients living in non-contaminated areas and 41 patients from 137Cs-contaminated areas. In contrast, a control group of 19 Spanish patients with analogue tumors were also investigated. For IHC evaluation, a tissue microarray technique was used. Decrease or loss and abnormal distribution of fibronectin, laminin, E-cadherin/beta-catenin complexes accompanied by elevated levels of p53 and TGF-beta1 were detected in the Ukrainian cRCCs from 137Cs-contaminated areas with statistically significant differences. Thus, our study suggests that chronic long-term, low-...Continue Reading

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Citations

Oct 13, 2009·Health Physics·Mary Helen Barcellos-Hoff, David H Nguyen
Mar 17, 2007·Current Problems in Cancer·Shian-Ying SungPeter A S Johnstone
Jul 27, 2011·Renal Failure·Viroj Wiwanitkit
May 6, 2014·Pathology Oncology Research : POR·Sergei V Jargin
Aug 28, 2014·Radiation Research·Sunirmal PaulSally A Amundson
Sep 25, 2014·Dose-response : a Publication of International Hormesis Society·Sergei V Jargin
May 12, 2007·Virchows Archiv : an International Journal of Pathology·Sergei V Jargin

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