Nov 6, 2014

Extracellular matrix assembly: a multiscale deconstruction

Nature Reviews. Molecular Cell Biology
Janna K MouwValerie M Weaver


The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.

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Mentioned in this Paper

Extracellular Matrix Assembly
Extracellular Matrix
Basement Membrane
Extracellular Matrix Proteins

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