Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues

Current Topics in Developmental Biology
Bette J Dzamba, Douglas W DeSimone

Abstract

Extracellular matrices (ECMs) are structurally and compositionally diverse networks of collagenous and noncollagenous glycoproteins, glycosaminoglycans, proteoglycans, and associated molecules that together comprise the metazoan matrisome. Proper deposition and assembly of ECM is of profound importance to cell proliferation, survival, and differentiation, and the morphogenesis of tissues and organ systems that define sequential steps in the development of all animals. Importantly, it is now clear that the instructive influence of a particular ECM at various points in development reflects more than a simple summing of component parts; cellular responses also reflect the dynamic assembly and changing topology of embryonic ECM, which in turn affect its biomechanical properties. This review highlights recent advances in understanding how biophysical features attributed to ECM, such as stiffness and viscoelasticity, play important roles in the sculpting of embryonic tissues and the regulation of cell fates. Forces generated within cells and tissues are transmitted both through integrin-based adhesions to ECM, and through cadherin-dependent cell-cell adhesions; the resulting short- and long-range deformations of embryonic tissues dri...Continue Reading

Citations

Jun 11, 2019·International Journal of Experimental Pathology·Kenneth M YamadaShaohe Wang
Apr 9, 2019·Open Biology·Katherine R Long, Wieland B Huttner
Aug 30, 2019·Essays in Biochemistry·Isra N Taha, Alexandra Naba
Oct 5, 2019·Nature Reviews. Molecular Cell Biology·Kenneth M Yamada, Michael Sixt
Dec 11, 2019·Journal of Developmental Biology·Emma F MatchettBryan D Crawford
Oct 6, 2019·Nucleic Acids Research·Xinhao ShaoAlexandra Naba
Feb 7, 2020·Journal of Developmental Biology·Christopher D SmallBryan D Crawford
Feb 6, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Steven Q Irvine
May 30, 2020·Development·David A Cruz Walma, Kenneth M Yamada
Sep 27, 2018·The Journal of Cell Biology·Benjamin T GoultMartin A Schwartz
Jan 21, 2021·Cell Reports·Antonia Weberling, Magdalena Zernicka-Goetz
Dec 16, 2020·Developmental Cell·Katharine Goodwin, Celeste M Nelson
Feb 15, 2021·Cellular and Molecular Life Sciences : CMLS·Lucy LeBlancJonghwan Kim
Feb 7, 2021·International Journal of Oral Science·Wei DuJimmy K Hu
Feb 27, 2021·PLoS Computational Biology·Inês G Gonçalves, Jose Manuel Garcia-Aznar
Mar 7, 2021·Gels·Xabier MoralesCarlos Ortiz-de-Solorzano
May 26, 2021·Seminars in Cell & Developmental Biology·Karen G Soans, Caren Norden
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Ting TsengJenny Ekberg
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gradimir MisevicOctavian Popescu
Jul 10, 2021·Annual Review of Cell and Developmental Biology·Yonit Maroudas-Sacks, Kinneret Keren

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