Extracellular matrix in cardiovascular pathophysiology

American Journal of Physiology. Heart and Circulatory Physiology
Maria BloksgaardLuis A Martinez-Lemus

Abstract

The extracellular matrix (ECM) actively participates in diverse aspects of cardiovascular development and physiology as well as during disease development and progression. ECM roles are determined by its physical and mechanical properties and by its capacity to both release bioactive signals and activate cell signaling pathways. The ECM serves as a storage depot for a wide variety of molecules released in response to injury or with aging. Indeed, there is a plethora of examples describing how cells react to or modify ECM stiffness, how cells initiate intracellular signaling pathways, and how cells respond to the ECM. This Perspectives article reviews the contributions of 21 articles published in the American Journal of Physiology-Heart and Circulatory Physiology in response to a Call for Papers on this topic. Here, we summarize the contributions of these studies focused on the cardiac and vascular ECM. We highlight the translational importance of these studies and conclude that the ECM is a critical component of both the heart and vasculature. Readers are urged to examine and learn from this special Call for Papers.

References

Oct 17, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Cesar A MeschiariMerry L Lindsey
Nov 24, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Daniel H CraigheadLacy M Alexander
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyGerd Heusch
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyMarielle Scherrer-Crosbie
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Heddwen L Brooks, Merry L Lindsey
Mar 3, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Russell H KnutsenBeth A Kozel
Mar 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Lindsay T McDonaldAmy D Bradshaw
Mar 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Junjing SuUlf Simonsen
Mar 31, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Alan J MoutonMerry L Lindsey
Apr 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Austin J CoccioloneJessica E Wagenseil
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·David A LiemJiaWei Han
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anika KleinJens Christian Brings Jacobsen
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Elia C El HajjJason D Gardner
Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·JoAnn Trial, Katarzyna A Cieslik
Jun 16, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Nethika R AriyasingheMegan L McCain
Jun 30, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Guohua LiFeng Gao
Jul 7, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Brendan P PurcellFrancis G Spinale
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Sarah J ParkerJennifer E Van Eyk
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Qing QinAmir Lerman
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Merry L LindseyDouglas Curran-Everett
Jul 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Laura R CaggianoJeffrey W Holmes

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Citations

Jul 9, 2020·JHEP Reports : Innovation in Hepatology·Gavin E Arteel, Alexandra Naba
Apr 11, 2021·Methods : a Companion to Methods in Enzymology·Pramod Sahadevan, Bruce G Allen
Jun 20, 2021·Scientific Reports·L B SteffensenL M Rasmussen
Dec 11, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Francisco I Ramirez-PerezGuido Lastra

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