Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization.

Frontiers in Bioengineering and Biotechnology
Dake HaoAijun Wang

Abstract

The network structure and biological components of natural extracellular matrix (ECM) are indispensable for promoting tissue regeneration. Electrospun nanofibrous scaffolds have been widely used in regenerative medicine to provide structural support for cell growth and tissue regeneration due to their natural ECM mimicking architecture, however, they lack biological functions. Extracellular vesicles (EVs) are potent vehicles of intercellular communication due to their ability to transfer RNAs, proteins, and lipids, thereby mediating significant biological functions in different biological systems. Matrix-bound nanovesicles (MBVs) are identified as an integral and functional component of ECM bioscaffolds mediating significant regenerative functions. Therefore, to engineer EVs modified electrospun scaffolds, mimicking the structure of the natural EV-ECM complex and the physiological interactions between the ECM and EVs, will be attractive and promising in tissue regeneration. Previously, using one-bead one-compound (OBOC) combinatorial technology, we identified LLP2A, an integrin α4β1 ligand, which had a strong binding to human placenta-derived mesenchymal stem cells (PMSCs). In this study, we isolated PMSCs derived EVs (PMSC-EVs...Continue Reading

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Citations

May 1, 2021·International Journal of Molecular Sciences·Allison MathiesenAnca Dobrian
May 1, 2021·Reproductive Biology·Prasad Pethe, Vaijayanti Kale
Aug 10, 2021·World Journal of Stem Cells·Aida NasirisharghAijun Wang

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Methods Mentioned

BETA
Transmission electron microscopy
Assay

Software Mentioned

Wimasis Image Analysis
ImageJ

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